The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development

Splenic marginal zone lymphoma (SMZL) is a B cell malignancy of unknown pathogenesis, and thus an orphan of targeted therapies. By integrating whole-exome sequencing and copy-number analysis, we show that the SMZL exome carries at least 30 nonsilent gene alterations. Mutations in NOTCH2, a gene requ...

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Detalles Bibliográficos
Autores principales: Rossi, Davide, Trifonov, Vladimir, Fangazio, Marco, Bruscaggin, Alessio, Rasi, Silvia, Spina, Valeria, Monti, Sara, Vaisitti, Tiziana, Arruga, Francesca, Famà, Rosella, Ciardullo, Carmela, Greco, Mariangela, Cresta, Stefania, Piranda, Daniela, Holmes, Antony, Fabbri, Giulia, Messina, Monica, Rinaldi, Andrea, Wang, Jiguang, Agostinelli, Claudio, Piccaluga, Pier Paolo, Lucioni, Marco, Tabbò, Fabrizio, Serra, Roberto, Franceschetti, Silvia, Deambrogi, Clara, Daniele, Giulia, Gattei, Valter, Marasca, Roberto, Facchetti, Fabio, Arcaini, Luca, Inghirami, Giorgio, Bertoni, Francesco, Pileri, Stefano A., Deaglio, Silvia, Foà, Robin, Dalla-Favera, Riccardo, Pasqualucci, Laura, Rabadan, Raul, Gaidano, Gianluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428941/
https://www.ncbi.nlm.nih.gov/pubmed/22891273
http://dx.doi.org/10.1084/jem.20120904

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