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Effects of n−3 Polyunsaturated Fatty Acids on Cardiac Ion Channels

Dietary n−3 polyunsaturated fatty acids (PUFAs) have been reported to exhibit antiarrhythmic properties, and these effects have been attributed to their capability to modulate ion channels. In the present review, we will focus on the effects of PUFAs on a cardiac sodium channel (Na(v)1.5) and two po...

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Autores principales: Moreno, Cristina, Macías, Álvaro, Prieto, Ángela, de la Cruz, Alicia, González, Teresa, Valenzuela, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429023/
https://www.ncbi.nlm.nih.gov/pubmed/22934003
http://dx.doi.org/10.3389/fphys.2012.00245
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author Moreno, Cristina
Macías, Álvaro
Prieto, Ángela
de la Cruz, Alicia
González, Teresa
Valenzuela, Carmen
author_facet Moreno, Cristina
Macías, Álvaro
Prieto, Ángela
de la Cruz, Alicia
González, Teresa
Valenzuela, Carmen
author_sort Moreno, Cristina
collection PubMed
description Dietary n−3 polyunsaturated fatty acids (PUFAs) have been reported to exhibit antiarrhythmic properties, and these effects have been attributed to their capability to modulate ion channels. In the present review, we will focus on the effects of PUFAs on a cardiac sodium channel (Na(v)1.5) and two potassium channels involved in cardiac atrial and ventricular repolarization (K(v)) (K(v)1.5 and K(v)11.1). n−3 PUFAs of marine (docosahexaenoic, DHA and eicosapentaenoic acid, EPA) and plant origin (alpha-linolenic acid, ALA) block K(v)1.5 and K(v)11.1 channels at physiological concentrations. Moreover, DHA and EPA decrease the expression levels of K(v)1.5, whereas ALA does not. DHA and EPA also decrease the magnitude of the currents elicited by the activation of Na(v)1.5 and calcium channels. These effects on sodium and calcium channels should theoretically shorten the cardiac action potential duration (APD), whereas the blocking actions of n−3 PUFAs on K(v) channels would be expected to produce a lengthening of cardiac action potential. Indeed, the effects of n−3 PUFAs on the cardiac APD and, therefore, on cardiac arrhythmias vary depending on the method of application, the animal model, and the underlying cardiac pathology.
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spelling pubmed-34290232012-08-29 Effects of n−3 Polyunsaturated Fatty Acids on Cardiac Ion Channels Moreno, Cristina Macías, Álvaro Prieto, Ángela de la Cruz, Alicia González, Teresa Valenzuela, Carmen Front Physiol Physiology Dietary n−3 polyunsaturated fatty acids (PUFAs) have been reported to exhibit antiarrhythmic properties, and these effects have been attributed to their capability to modulate ion channels. In the present review, we will focus on the effects of PUFAs on a cardiac sodium channel (Na(v)1.5) and two potassium channels involved in cardiac atrial and ventricular repolarization (K(v)) (K(v)1.5 and K(v)11.1). n−3 PUFAs of marine (docosahexaenoic, DHA and eicosapentaenoic acid, EPA) and plant origin (alpha-linolenic acid, ALA) block K(v)1.5 and K(v)11.1 channels at physiological concentrations. Moreover, DHA and EPA decrease the expression levels of K(v)1.5, whereas ALA does not. DHA and EPA also decrease the magnitude of the currents elicited by the activation of Na(v)1.5 and calcium channels. These effects on sodium and calcium channels should theoretically shorten the cardiac action potential duration (APD), whereas the blocking actions of n−3 PUFAs on K(v) channels would be expected to produce a lengthening of cardiac action potential. Indeed, the effects of n−3 PUFAs on the cardiac APD and, therefore, on cardiac arrhythmias vary depending on the method of application, the animal model, and the underlying cardiac pathology. Frontiers Research Foundation 2012-07-09 /pmc/articles/PMC3429023/ /pubmed/22934003 http://dx.doi.org/10.3389/fphys.2012.00245 Text en Copyright © 2012 Moreno, Macías, Prieto, de la Cruz, González and Valenzuela. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Physiology
Moreno, Cristina
Macías, Álvaro
Prieto, Ángela
de la Cruz, Alicia
González, Teresa
Valenzuela, Carmen
Effects of n−3 Polyunsaturated Fatty Acids on Cardiac Ion Channels
title Effects of n−3 Polyunsaturated Fatty Acids on Cardiac Ion Channels
title_full Effects of n−3 Polyunsaturated Fatty Acids on Cardiac Ion Channels
title_fullStr Effects of n−3 Polyunsaturated Fatty Acids on Cardiac Ion Channels
title_full_unstemmed Effects of n−3 Polyunsaturated Fatty Acids on Cardiac Ion Channels
title_short Effects of n−3 Polyunsaturated Fatty Acids on Cardiac Ion Channels
title_sort effects of n−3 polyunsaturated fatty acids on cardiac ion channels
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429023/
https://www.ncbi.nlm.nih.gov/pubmed/22934003
http://dx.doi.org/10.3389/fphys.2012.00245
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