Crystal Structures of Three Classes of Non-Steroidal Anti-Inflammatory Drugs in Complex with Aldo-Keto Reductase 1C3

Aldo-keto reductase 1C3 (AKR1C3) catalyses the NADPH dependent reduction of carbonyl groups in a number of important steroid and prostanoid molecules. The enzyme is also over-expressed in prostate and breast cancer and its expression is correlated with the aggressiveness of the disease. The steroid...

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Detalles Bibliográficos
Autores principales: Flanagan, Jack U., Yosaatmadja, Yuliana, Teague, Rebecca M., Chai, Matilda Z. L., Turnbull, Andrew P., Squire, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429426/
https://www.ncbi.nlm.nih.gov/pubmed/22937138
http://dx.doi.org/10.1371/journal.pone.0043965

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