Prevalence of c-KIT Mutations in Gonadoblastoma and Dysgerminomas of Patients with Disorders of Sex Development (DSD) and Ovarian Dysgerminomas

Activating c-KIT mutations (exons 11 and 17) are found in 10–40% of testicular seminomas, the majority being missense point mutations (codon 816). Malignant ovarian dysgerminomas represent ∼3% of all ovarian cancers in Western countries, resembling testicular seminomas, regarding chromosomal aberrat...

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Detalles Bibliográficos
Autores principales: Hersmus, Remko, Stoop, Hans, van de Geijn, Gert Jan, Eini, Ronak, Biermann, Katharina, Oosterhuis, J. Wolter, DHooge, Catharina, Schneider, Dominik T., Meijssen, Isabelle C., Dinjens, Winand N. M., Dubbink, Hendrikus Jan, Drop, Stenvert L. S., Looijenga, Leendert H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429439/
https://www.ncbi.nlm.nih.gov/pubmed/22937135
http://dx.doi.org/10.1371/journal.pone.0043952

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