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Prenatal Exposure to Bereavement and Type-2 Diabetes: A Danish Longitudinal Population Based Study
BACKGROUND: The etiology of type-2 diabetes is only partly known, and a possible role of prenatal stress in programming offspring for insulin resistance has been suggested by animal models. Previously, we found an association between prenatal stress and type-1 diabetes. Here we examine the associati...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429491/ https://www.ncbi.nlm.nih.gov/pubmed/22952698 http://dx.doi.org/10.1371/journal.pone.0043508 |
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author | Li, Jiong Olsen, Jørn Vestergaard, Mogens Obel, Carsten Kristensen, Jette Kolding Virk, Jasveer |
author_facet | Li, Jiong Olsen, Jørn Vestergaard, Mogens Obel, Carsten Kristensen, Jette Kolding Virk, Jasveer |
author_sort | Li, Jiong |
collection | PubMed |
description | BACKGROUND: The etiology of type-2 diabetes is only partly known, and a possible role of prenatal stress in programming offspring for insulin resistance has been suggested by animal models. Previously, we found an association between prenatal stress and type-1 diabetes. Here we examine the association between prenatal exposure to maternal bereavement during preconception and pregnancy and development of type-2 diabetes in the off-spring. METHODS: We utilized data from the Danish Civil Registration System to identify singleton births in Denmark born January 1(st) 1979 through December 31(st) 2008 (N = 1,878,246), and linked them to their parents, grandparents, and siblings. We categorized children as exposed to bereavement during prenatal life if their mothers lost an elder child, husband or parent during the period from one year before conception to the child’s birth. We identified 45,302 children exposed to maternal bereavement; the remaining children were included in the unexposed cohort. The outcome of interest was diagnosis of type-2 diabetes. We estimated incidence rate ratios (IRRs) from birth using log-linear poisson regression models and used person-years as the offset variable. All models were adjusted for maternal residence, income, education, marital status, sibling order, calendar year, sex, and parents’ history of diabetes at the time of pregnancy. RESULTS: We found children exposed to bereavement during their prenatal life were more likely to have a type-2 diabetes diagnosis later in life (aIRR: 1.31, 1.01–1.69). These findings were most pronounced when bereavement was caused by death of an elder child (aIRR: 1.51, 0.94–2.44). Results also indicated the second trimester of pregnancy to be the most sensitive period of bereavement exposure (aIRR:2.08, 1.15–3.76). CONCLUSIONS: Our data suggests that fetal exposure to maternal bereavement during preconception and the prenatal period may increase the risk for developing type-2 diabetes in childhood and young adulthood. |
format | Online Article Text |
id | pubmed-3429491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-34294912012-09-05 Prenatal Exposure to Bereavement and Type-2 Diabetes: A Danish Longitudinal Population Based Study Li, Jiong Olsen, Jørn Vestergaard, Mogens Obel, Carsten Kristensen, Jette Kolding Virk, Jasveer PLoS One Research Article BACKGROUND: The etiology of type-2 diabetes is only partly known, and a possible role of prenatal stress in programming offspring for insulin resistance has been suggested by animal models. Previously, we found an association between prenatal stress and type-1 diabetes. Here we examine the association between prenatal exposure to maternal bereavement during preconception and pregnancy and development of type-2 diabetes in the off-spring. METHODS: We utilized data from the Danish Civil Registration System to identify singleton births in Denmark born January 1(st) 1979 through December 31(st) 2008 (N = 1,878,246), and linked them to their parents, grandparents, and siblings. We categorized children as exposed to bereavement during prenatal life if their mothers lost an elder child, husband or parent during the period from one year before conception to the child’s birth. We identified 45,302 children exposed to maternal bereavement; the remaining children were included in the unexposed cohort. The outcome of interest was diagnosis of type-2 diabetes. We estimated incidence rate ratios (IRRs) from birth using log-linear poisson regression models and used person-years as the offset variable. All models were adjusted for maternal residence, income, education, marital status, sibling order, calendar year, sex, and parents’ history of diabetes at the time of pregnancy. RESULTS: We found children exposed to bereavement during their prenatal life were more likely to have a type-2 diabetes diagnosis later in life (aIRR: 1.31, 1.01–1.69). These findings were most pronounced when bereavement was caused by death of an elder child (aIRR: 1.51, 0.94–2.44). Results also indicated the second trimester of pregnancy to be the most sensitive period of bereavement exposure (aIRR:2.08, 1.15–3.76). CONCLUSIONS: Our data suggests that fetal exposure to maternal bereavement during preconception and the prenatal period may increase the risk for developing type-2 diabetes in childhood and young adulthood. Public Library of Science 2012-08-28 /pmc/articles/PMC3429491/ /pubmed/22952698 http://dx.doi.org/10.1371/journal.pone.0043508 Text en © 2012 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Li, Jiong Olsen, Jørn Vestergaard, Mogens Obel, Carsten Kristensen, Jette Kolding Virk, Jasveer Prenatal Exposure to Bereavement and Type-2 Diabetes: A Danish Longitudinal Population Based Study |
title | Prenatal Exposure to Bereavement and Type-2 Diabetes: A Danish Longitudinal Population Based Study |
title_full | Prenatal Exposure to Bereavement and Type-2 Diabetes: A Danish Longitudinal Population Based Study |
title_fullStr | Prenatal Exposure to Bereavement and Type-2 Diabetes: A Danish Longitudinal Population Based Study |
title_full_unstemmed | Prenatal Exposure to Bereavement and Type-2 Diabetes: A Danish Longitudinal Population Based Study |
title_short | Prenatal Exposure to Bereavement and Type-2 Diabetes: A Danish Longitudinal Population Based Study |
title_sort | prenatal exposure to bereavement and type-2 diabetes: a danish longitudinal population based study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429491/ https://www.ncbi.nlm.nih.gov/pubmed/22952698 http://dx.doi.org/10.1371/journal.pone.0043508 |
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