The downward spiral of tau and autolysosomes: A new hypothesis in neurodegeneration

A growing body of research has connected autophagy to neurodegenerative diseases such as Alzheimer disease (AD). In autopsied AD brain, large multivesicular bodies accumulate in neurons. Knockout mice deficient for key autophagy genes demonstrate age-dependent neurodegeneration. Most neurodegenerati...

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Detalles Bibliográficos
Autores principales: Ambegaokar, Suren S., Jackson, George R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Autophagic Punctum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429552/
https://www.ncbi.nlm.nih.gov/pubmed/22635052
http://dx.doi.org/10.4161/auto.20515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429552/
https://www.ncbi.nlm.nih.gov/pubmed/22635052
http://dx.doi.org/10.4161/auto.20515

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