Bcl-2: Live and let die

Recent findings from our laboratory provide the first indication that overexpression of Bcl-2 in Eµ-myc transgenic cells enhances tumor immunosurveillance by inducing NKG2D ligands. Initial evidence suggests that this model is relevant to human patients. Thus, antitumor therapies that target Bcl-2 h...

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Detalles Bibliográficos
Autores principales: Putz, Eva Maria, Schuster, Christian, Sexl, Veronika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429582/
https://www.ncbi.nlm.nih.gov/pubmed/22934270
http://dx.doi.org/10.4161/onci.19536
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author Putz, Eva Maria
Schuster, Christian
Sexl, Veronika
author_facet Putz, Eva Maria
Schuster, Christian
Sexl, Veronika
author_sort Putz, Eva Maria
collection PubMed
description Recent findings from our laboratory provide the first indication that overexpression of Bcl-2 in Eµ-myc transgenic cells enhances tumor immunosurveillance by inducing NKG2D ligands. Initial evidence suggests that this model is relevant to human patients. Thus, antitumor therapies that target Bcl-2 harbor the risk of reducing tumor immunogenicity.
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spelling pubmed-34295822012-08-29 Bcl-2: Live and let die Putz, Eva Maria Schuster, Christian Sexl, Veronika Oncoimmunology Author's View Recent findings from our laboratory provide the first indication that overexpression of Bcl-2 in Eµ-myc transgenic cells enhances tumor immunosurveillance by inducing NKG2D ligands. Initial evidence suggests that this model is relevant to human patients. Thus, antitumor therapies that target Bcl-2 harbor the risk of reducing tumor immunogenicity. Landes Bioscience 2012-08-01 /pmc/articles/PMC3429582/ /pubmed/22934270 http://dx.doi.org/10.4161/onci.19536 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Putz, Eva Maria
Schuster, Christian
Sexl, Veronika
Bcl-2: Live and let die
title Bcl-2: Live and let die
title_full Bcl-2: Live and let die
title_fullStr Bcl-2: Live and let die
title_full_unstemmed Bcl-2: Live and let die
title_short Bcl-2: Live and let die
title_sort bcl-2: live and let die
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429582/
https://www.ncbi.nlm.nih.gov/pubmed/22934270
http://dx.doi.org/10.4161/onci.19536
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AT schusterchristian bcl2liveandletdie
AT sexlveronika bcl2liveandletdie

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