New strategies for melanoma immunotherapy: How to overcome immunosuppression in the tumor microenvironment

Using ret transgenic mouse model of spontaneous melanoma, we showed an accumulation of melanoma antigen-specific memory T cells. However, their antitumor effects could be blocked by myeloid-derived suppressor cells, tolerogenic dendritic cells and regulatory T cells. We suggest that effective melano...

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Detalles Bibliográficos
Autor principal: Umansky, Viktor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429588/
https://www.ncbi.nlm.nih.gov/pubmed/22934276
http://dx.doi.org/10.4161/onci.19713
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author Umansky, Viktor
author_facet Umansky, Viktor
author_sort Umansky, Viktor
collection PubMed
description Using ret transgenic mouse model of spontaneous melanoma, we showed an accumulation of melanoma antigen-specific memory T cells. However, their antitumor effects could be blocked by myeloid-derived suppressor cells, tolerogenic dendritic cells and regulatory T cells. We suggest that effective melanoma immunotherapy should include the neutralization of immunosuppressive tumor microenvironment.
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spelling pubmed-34295882012-08-29 New strategies for melanoma immunotherapy: How to overcome immunosuppression in the tumor microenvironment Umansky, Viktor Oncoimmunology Author's View Using ret transgenic mouse model of spontaneous melanoma, we showed an accumulation of melanoma antigen-specific memory T cells. However, their antitumor effects could be blocked by myeloid-derived suppressor cells, tolerogenic dendritic cells and regulatory T cells. We suggest that effective melanoma immunotherapy should include the neutralization of immunosuppressive tumor microenvironment. Landes Bioscience 2012-08-01 /pmc/articles/PMC3429588/ /pubmed/22934276 http://dx.doi.org/10.4161/onci.19713 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Umansky, Viktor
New strategies for melanoma immunotherapy: How to overcome immunosuppression in the tumor microenvironment
title New strategies for melanoma immunotherapy: How to overcome immunosuppression in the tumor microenvironment
title_full New strategies for melanoma immunotherapy: How to overcome immunosuppression in the tumor microenvironment
title_fullStr New strategies for melanoma immunotherapy: How to overcome immunosuppression in the tumor microenvironment
title_full_unstemmed New strategies for melanoma immunotherapy: How to overcome immunosuppression in the tumor microenvironment
title_short New strategies for melanoma immunotherapy: How to overcome immunosuppression in the tumor microenvironment
title_sort new strategies for melanoma immunotherapy: how to overcome immunosuppression in the tumor microenvironment
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429588/
https://www.ncbi.nlm.nih.gov/pubmed/22934276
http://dx.doi.org/10.4161/onci.19713
work_keys_str_mv AT umanskyviktor newstrategiesformelanomaimmunotherapyhowtoovercomeimmunosuppressioninthetumormicroenvironment

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