Combining targeted therapy with immunotherapy (interferon-α): Rational, efficacy in gastrointestinal stromal tumor model and implications in other malignancies

Imatinib revolutionized gastrointestinal stromal tumor (GIST) treatment but median-progression-free-survival of unresectable/metastatic disease is < 2 y. B-RAF(V600)-mutated-melanoma responds to vemurafenib dramatically but median-progression-free-survival is < 9 mo. Combining imatinib with im...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Lei L., Gouw, Launce, Sabripour, Mahyar, Hwu, Wen-Jen, Benjamin, Robert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429591/
https://www.ncbi.nlm.nih.gov/pubmed/22934279
http://dx.doi.org/10.4161/onci.19729
_version_ 1782241824402833408
author Chen, Lei L.
Gouw, Launce
Sabripour, Mahyar
Hwu, Wen-Jen
Benjamin, Robert S.
author_facet Chen, Lei L.
Gouw, Launce
Sabripour, Mahyar
Hwu, Wen-Jen
Benjamin, Robert S.
author_sort Chen, Lei L.
collection PubMed
description Imatinib revolutionized gastrointestinal stromal tumor (GIST) treatment but median-progression-free-survival of unresectable/metastatic disease is < 2 y. B-RAF(V600)-mutated-melanoma responds to vemurafenib dramatically but median-progression-free-survival is < 9 mo. Combining imatinib with immunotherapy (peginterferon α-2b) in GIST showed significant induction of antitumor immunity and highly promising clinical outcomes. This strategy warrants further testing in other malignancies.
format Online
Article
Text
id pubmed-3429591
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-34295912012-08-29 Combining targeted therapy with immunotherapy (interferon-α): Rational, efficacy in gastrointestinal stromal tumor model and implications in other malignancies Chen, Lei L. Gouw, Launce Sabripour, Mahyar Hwu, Wen-Jen Benjamin, Robert S. Oncoimmunology Author's View Imatinib revolutionized gastrointestinal stromal tumor (GIST) treatment but median-progression-free-survival of unresectable/metastatic disease is < 2 y. B-RAF(V600)-mutated-melanoma responds to vemurafenib dramatically but median-progression-free-survival is < 9 mo. Combining imatinib with immunotherapy (peginterferon α-2b) in GIST showed significant induction of antitumor immunity and highly promising clinical outcomes. This strategy warrants further testing in other malignancies. Landes Bioscience 2012-08-01 /pmc/articles/PMC3429591/ /pubmed/22934279 http://dx.doi.org/10.4161/onci.19729 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Chen, Lei L.
Gouw, Launce
Sabripour, Mahyar
Hwu, Wen-Jen
Benjamin, Robert S.
Combining targeted therapy with immunotherapy (interferon-α): Rational, efficacy in gastrointestinal stromal tumor model and implications in other malignancies
title Combining targeted therapy with immunotherapy (interferon-α): Rational, efficacy in gastrointestinal stromal tumor model and implications in other malignancies
title_full Combining targeted therapy with immunotherapy (interferon-α): Rational, efficacy in gastrointestinal stromal tumor model and implications in other malignancies
title_fullStr Combining targeted therapy with immunotherapy (interferon-α): Rational, efficacy in gastrointestinal stromal tumor model and implications in other malignancies
title_full_unstemmed Combining targeted therapy with immunotherapy (interferon-α): Rational, efficacy in gastrointestinal stromal tumor model and implications in other malignancies
title_short Combining targeted therapy with immunotherapy (interferon-α): Rational, efficacy in gastrointestinal stromal tumor model and implications in other malignancies
title_sort combining targeted therapy with immunotherapy (interferon-α): rational, efficacy in gastrointestinal stromal tumor model and implications in other malignancies
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429591/
https://www.ncbi.nlm.nih.gov/pubmed/22934279
http://dx.doi.org/10.4161/onci.19729
work_keys_str_mv AT chenleil combiningtargetedtherapywithimmunotherapyinterferonarationalefficacyingastrointestinalstromaltumormodelandimplicationsinothermalignancies
AT gouwlaunce combiningtargetedtherapywithimmunotherapyinterferonarationalefficacyingastrointestinalstromaltumormodelandimplicationsinothermalignancies
AT sabripourmahyar combiningtargetedtherapywithimmunotherapyinterferonarationalefficacyingastrointestinalstromaltumormodelandimplicationsinothermalignancies
AT hwuwenjen combiningtargetedtherapywithimmunotherapyinterferonarationalefficacyingastrointestinalstromaltumormodelandimplicationsinothermalignancies
AT benjaminroberts combiningtargetedtherapywithimmunotherapyinterferonarationalefficacyingastrointestinalstromaltumormodelandimplicationsinothermalignancies

Ejemplares similares