Effect of CpG ODN on monocytic myeloid derived suppressor cells

CpG oligonucleotides stimulate via TLR9 and enhance anti-tumor immunity, an effect attributed to the activation of NK and CD8(+) T cells. Our recent work demonstrates that CpG ODN also induce monocytic myeloid-derived suppressor cells to mature into M1 macrophages, further aiding tumor elimination....

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Detalles Bibliográficos
Autores principales: Shirota, Hidekazu, Klinman, Dennis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429593/
https://www.ncbi.nlm.nih.gov/pubmed/22934281
http://dx.doi.org/10.4161/onci.19731
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author Shirota, Hidekazu
Klinman, Dennis M.
author_facet Shirota, Hidekazu
Klinman, Dennis M.
author_sort Shirota, Hidekazu
collection PubMed
description CpG oligonucleotides stimulate via TLR9 and enhance anti-tumor immunity, an effect attributed to the activation of NK and CD8(+) T cells. Our recent work demonstrates that CpG ODN also induce monocytic myeloid-derived suppressor cells to mature into M1 macrophages, further aiding tumor elimination. This provides insight into the mechanism through which CpG promote tumor regression.
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spelling pubmed-34295932012-08-29 Effect of CpG ODN on monocytic myeloid derived suppressor cells Shirota, Hidekazu Klinman, Dennis M. Oncoimmunology Author's View CpG oligonucleotides stimulate via TLR9 and enhance anti-tumor immunity, an effect attributed to the activation of NK and CD8(+) T cells. Our recent work demonstrates that CpG ODN also induce monocytic myeloid-derived suppressor cells to mature into M1 macrophages, further aiding tumor elimination. This provides insight into the mechanism through which CpG promote tumor regression. Landes Bioscience 2012-08-01 /pmc/articles/PMC3429593/ /pubmed/22934281 http://dx.doi.org/10.4161/onci.19731 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Shirota, Hidekazu
Klinman, Dennis M.
Effect of CpG ODN on monocytic myeloid derived suppressor cells
title Effect of CpG ODN on monocytic myeloid derived suppressor cells
title_full Effect of CpG ODN on monocytic myeloid derived suppressor cells
title_fullStr Effect of CpG ODN on monocytic myeloid derived suppressor cells
title_full_unstemmed Effect of CpG ODN on monocytic myeloid derived suppressor cells
title_short Effect of CpG ODN on monocytic myeloid derived suppressor cells
title_sort effect of cpg odn on monocytic myeloid derived suppressor cells
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429593/
https://www.ncbi.nlm.nih.gov/pubmed/22934281
http://dx.doi.org/10.4161/onci.19731
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