The emergence of phox-ER stress induced immunogenic apoptosis

Primary induction of photo-oxidative (phox)-ER stress in cancer cells evoked immunogenic apoptosis (IA) associated with pre-apoptotic emission of calreticulin and ATP, and protective antitumor immunity. This IA subroutine involved “core” functions (e.g., PERK/PI3K-based modulation of secretory traff...

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Detalles Bibliográficos
Autores principales: Garg, Abhishek D., Krysko, Dmitri V., Vandenabeele, Peter, Agostinis, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429595/
https://www.ncbi.nlm.nih.gov/pubmed/22934283
http://dx.doi.org/10.4161/onci.19750
Descripción
Sumario:Primary induction of photo-oxidative (phox)-ER stress in cancer cells evoked immunogenic apoptosis (IA) associated with pre-apoptotic emission of calreticulin and ATP, and protective antitumor immunity. This IA subroutine involved “core” functions (e.g., PERK/PI3K-based modulation of secretory trafficking) rather than “private” ones (caspase-8 and eIF2α-phosphorylation) engaged by other IA inducers.

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