X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells

We show that sufficient concentrations of gold nanoparticles produced by an original synthesis method in EMT-6 and CT-26 cancer cells make it possible to detect the presence, necrosis and proliferation of such cells after inoculation in live mice. We first demonstrated that the nanoparticles do not...

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Autores principales: Chien, Chia-Chi, Chen, Hsiang-Hsin, Lai, Sheng-Feng, Hwu, Y., Petibois, Cyril, Yang, C. S., Chu, Y., Margaritondo, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429882/
https://www.ncbi.nlm.nih.gov/pubmed/22934133
http://dx.doi.org/10.1038/srep00610
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author Chien, Chia-Chi
Chen, Hsiang-Hsin
Lai, Sheng-Feng
Hwu, Y.
Petibois, Cyril
Yang, C. S.
Chu, Y.
Margaritondo, G.
author_facet Chien, Chia-Chi
Chen, Hsiang-Hsin
Lai, Sheng-Feng
Hwu, Y.
Petibois, Cyril
Yang, C. S.
Chu, Y.
Margaritondo, G.
author_sort Chien, Chia-Chi
collection PubMed
description We show that sufficient concentrations of gold nanoparticles produced by an original synthesis method in EMT-6 and CT-26 cancer cells make it possible to detect the presence, necrosis and proliferation of such cells after inoculation in live mice. We first demonstrated that the nanoparticles do not interfere with the proliferation process. Then, we observed significant differences in the tumor evolution and the angiogenesis process after shallow and deep inoculation. A direct comparison with pathology optical images illustrates the effectiveness of this approach.
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spelling pubmed-34298822012-08-29 X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells Chien, Chia-Chi Chen, Hsiang-Hsin Lai, Sheng-Feng Hwu, Y. Petibois, Cyril Yang, C. S. Chu, Y. Margaritondo, G. Sci Rep Article We show that sufficient concentrations of gold nanoparticles produced by an original synthesis method in EMT-6 and CT-26 cancer cells make it possible to detect the presence, necrosis and proliferation of such cells after inoculation in live mice. We first demonstrated that the nanoparticles do not interfere with the proliferation process. Then, we observed significant differences in the tumor evolution and the angiogenesis process after shallow and deep inoculation. A direct comparison with pathology optical images illustrates the effectiveness of this approach. Nature Publishing Group 2012-08-29 /pmc/articles/PMC3429882/ /pubmed/22934133 http://dx.doi.org/10.1038/srep00610 Text en Copyright © 2012, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Article
Chien, Chia-Chi
Chen, Hsiang-Hsin
Lai, Sheng-Feng
Hwu, Y.
Petibois, Cyril
Yang, C. S.
Chu, Y.
Margaritondo, G.
X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells
title X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells
title_full X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells
title_fullStr X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells
title_full_unstemmed X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells
title_short X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells
title_sort x-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429882/
https://www.ncbi.nlm.nih.gov/pubmed/22934133
http://dx.doi.org/10.1038/srep00610
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