Human cells enter mitosis with damaged DNA after treatment with pharmacological concentrations of genotoxic agents

In the present paper, we report that mitosis is a key step in the cellular response to genotoxic agents in human cells. Cells with damaged DNA recruit γH2AX (phosphorylated histone H2AX), phosphorylate Chk1 (checkpoint kinase 1) and arrest in the G(2)-phase of the cell cycle. Strikingly, nearly all...

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Detalles Bibliográficos
Autores principales: Kubara, Philip M., Kernéis-Golsteyn, Sophie, Studény, Aurélie, Lanser, Brittany B., Meijer, Laurent, Golsteyn, Roy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430003/
https://www.ncbi.nlm.nih.gov/pubmed/22686412
http://dx.doi.org/10.1042/BJ20120385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430003/
https://www.ncbi.nlm.nih.gov/pubmed/22686412
http://dx.doi.org/10.1042/BJ20120385

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