Cargando…

Human cells enter mitosis with damaged DNA after treatment with pharmacological concentrations of genotoxic agents

In the present paper, we report that mitosis is a key step in the cellular response to genotoxic agents in human cells. Cells with damaged DNA recruit γH2AX (phosphorylated histone H2AX), phosphorylate Chk1 (checkpoint kinase 1) and arrest in the G(2)-phase of the cell cycle. Strikingly, nearly all...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kubara, Philip M., Kernéis-Golsteyn, Sophie, Studény, Aurélie, Lanser, Brittany B., Meijer, Laurent, Golsteyn, Roy M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430003/ https://www.ncbi.nlm.nih.gov/pubmed/22686412 http://dx.doi.org/10.1042/BJ20120385

Ejemplares similares

Genotoxic Anti-Cancer Agents and Their Relationship to DNA Damage, Mitosis, and Checkpoint Adaptation in Proliferating Cancer Cells
por: Swift, Lucy H., et al.
Publicado: (2014)

G2/M-Phase Checkpoint Adaptation and Micronuclei Formation as Mechanisms That Contribute to Genomic Instability in Human Cells
por: Kalsbeek, Danî, et al.
Publicado: (2017)

Emerging Anti-Mitotic Activities and Other Bioactivities of Sesquiterpene Compounds upon Human Cells
por: Bosco, Alessandra, et al.
Publicado: (2017)

Are estimates of intergenerational mobility biased by non-response? Evidence from the Netherlands
por: Golsteyn, Bart H. H., et al.
Publicado: (2018)

Isolation of a natural product with anti-mitotic activity from a toxic Canadian prairie plant
por: Molina, Layla, et al.
Publicado: (2021)

School Quality and the Development of Cognitive Skills between Age Four and Six
por: Borghans, Lex, et al.
Publicado: (2015)

Does Expert Advice Improve Educational Choice?
por: Borghans, Lex, et al.
Publicado: (2015)

Deceased by default: Consent systems and organ-patient mortality
por: Golsteyn, Bart H. H., et al.
Publicado: (2021)

Personality traits and academic performance: Correcting self-assessed traits with vignettes
por: Coenen, Johan, et al.
Publicado: (2021)

Intraguild Interactions between the Mealybug Predators Cryptolaemus montrouzieri and Chrysoperla carnea
por: Golsteyn, Laura, et al.
Publicado: (2021)

Extracts Prepared from a Canadian Toxic Plant Induce Light-Dependent Perinuclear Vacuoles in Human Cells
por: Tuescher, Jan M., et al.
Publicado: (2021)

Non-coding RNAs enter mitosis: functions, conservation and implications
por: Pek, Jun Wei, et al.
Publicado: (2011)

The decision to enter mitosis: feedback and redundancy in the mitotic entry network
por: Lindqvist, Arne, et al.
Publicado: (2009)

Genotoxic effects of airborne agents
por: Tice, Raymund, et al.
Publicado: (1982)

Anti-tumor pharmacology of natural products targeting mitosis
por: Huang, Manru, et al.
Publicado: (2022)

FOXM1: An emerging master regulator of DNA damage response and genotoxic agent resistance
por: Zona, Stefania, et al.
Publicado: (2014)

Linking abnormal mitosis to the acquisition of DNA damage
por: Ganem, Neil J., et al.
Publicado: (2012)

The LIV-1-GRPEL1 axis adjusts cell fate during anti-mitotic agent-damaged mitosis
por: Chen, Pingbo, et al.
Publicado: (2019)

Inhibition of Chk1 Kills Tetraploid Tumor Cells through a p53-Dependent Pathway
por: Vitale, Ilio, et al.
Publicado: (2007)

Individual susceptibility to genotoxic agents in the human population
por: Serres, Frederick, et al.
Publicado: (1984)

CDKB2 is involved in mitosis and DNA damage response in rice
por: Endo, Masaki, et al.
Publicado: (2012)

Risk of genotoxic damage in schoolchildren exposed to organochloride pesticides
por: Anguiano-Vega, Gerardo Alfonso, et al.
Publicado: (2020)

Genotoxicity, DNA damage and sperm defects induced by vinblastine
por: Fahmy, Maha A., et al.
Publicado: (2022)

Rhythm in mitosis and cytoplasmic solid concentration in Landschütz ascites tumour cells.
por: Galbraith, W., et al.
Publicado: (1965)

DNA damage signaling in response to double-strand breaks during mitosis
por: Giunta, Simona, et al.
Publicado: (2010)

DNA damage induced during mitosis undergoes DNA repair synthesis
por: Gomez Godinez, Veronica, et al.
Publicado: (2020)

Prolongation of mitosis is associated with enhanced endogenous DNA damage in fission yeast.
por: Jain, Ishutesh, et al.
Publicado: (2023)

Genotoxic Agents Promote the Nuclear Accumulation of Annexin A2: Role of Annexin A2 in Mitigating DNA Damage
por: Madureira, Patricia A., et al.
Publicado: (2012)

Attenuation of cGAS/STING activity during mitosis
por: Uhlorn, Brittany L, et al.
Publicado: (2020)

Wip1 downregulation conserves truncated DNA damage response (DDR) in mitosis
por: Vaz, Bruno, et al.
Publicado: (2013)

Polo-like kinase 1 inhibits DNA damage response during mitosis
por: Benada, Jan, et al.
Publicado: (2015)

Committing to mitosis
por: Wells, William A.
Publicado: (2003)

Integrins for mitosis
por: LeBrasseur, Nicole
Publicado: (2006)

The Cell in Mitosis
por: Lubs, Herbert A.
Publicado: (1964)

Mitosis is swell
por: Zatulovskiy, Evgeny, et al.
Publicado: (2015)

Thresholds of Genotoxic and Non-Genotoxic Carcinogens
por: Nohmi, Takehiko
Publicado: (2018)

Genotoxic Damage During Brain Development Presages Prototypical Neurodegenerative Disease
por: Kisby, Glen E., et al.
Publicado: (2021)

Microtubules are necessary for proper Reticulon localization during mitosis
por: Diaz, Ulises, et al.
Publicado: (2019)

The HPRT short-term assay in monitoring individuals exposed to genotoxic agents.
por: Montero, R, et al.
Publicado: (1993)

Critical effective methods to detect genotoxic carcinogens and neoplasm-promoting agents.
por: Weisburger, J H, et al.
Publicado: (1991)

Cannot write session to /tmp/vufind_sessions/sess_r3ne4g2qq4h4bjhe7mlid6s56o