Cargando…

Acute phase reactant dynamics and incidence of microvascular dysfunctions in type 2 diabetes mellitus

BACKGROUND: Acute Phase Reactants (APRs) have a wide range of activities that contribute to host defense. The aim of this report was to evaluate the dynamics and magnitude of these proteins in various microvascular complications in diabetes mellitus (DM). We also sought to assess the predictive valu...

Descripción completa

Detalles Bibliográficos
Autores principales: Azenabor, Alfred, Ogbera, Anthonia O., Adejumo, Ngozi E., Adejare, Adejimi O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430019/
https://www.ncbi.nlm.nih.gov/pubmed/22973323
_version_ 1782241886254137344
author Azenabor, Alfred
Ogbera, Anthonia O.
Adejumo, Ngozi E.
Adejare, Adejimi O.
author_facet Azenabor, Alfred
Ogbera, Anthonia O.
Adejumo, Ngozi E.
Adejare, Adejimi O.
author_sort Azenabor, Alfred
collection PubMed
description BACKGROUND: Acute Phase Reactants (APRs) have a wide range of activities that contribute to host defense. The aim of this report was to evaluate the dynamics and magnitude of these proteins in various microvascular complications in diabetes mellitus (DM). We also sought to assess the predictive values of APRs and other clinical variables for microvascular complications in DM. METHODS: This was a case control study carried out in 200 Nigerian subjects with type 2 DM and 100 sex and age matched healthy controls. The studied APRs included C-reactive protein, beta 2 microglobulin, fibrinogen and lipoprotein (a). RESULTS: The mean values of the APRs were significantly higher in type 2 DM compared with the controls and were observed in higher concentrations in those with microvascular complications, except beta 2 microglobulin. Presence of microvascular complications was observed in those with dilated fundus examination (retinopathy), symptom score of 3.0 (neuropathy), urea and creatinine levels above 50mg% and 1.5mg%, respectively, with significant proteinuria (nephropathy). Significant increase in mean ± SEM values of lipoprotein (a) was observed in diabetic retinopathy in comparison with those without complications (25.76 ± 1.13 mg/dl vs. 22.37 ± 0.73 mg/dl, p = 0.005). Elevated C-reactive protein was observed in diabetic neuropathy in comparison with those without complications (11.43 ± 2.33 u/ml vs. 8.30 ± 1.15 u/ml, p = 0.048). Increased beta 2 microglobulin levels were observed in patients with diabetic foot ulcers in comparison with those without complications (3.04 ± 0.51 mg/dl vs. 2.54 ± 0.14 mg/dl, p = 0.049). Circulating levels of Lipoprotein (a) predicted retinopathy in DM with both good and poor long-term glycemic control while duration of DM predicted the occurrence of foot ulcers.. CONCLUSIONS: Increased level of APRs was associated with a number of microvascular complications and may play a role in the pathogenesis.
format Online
Article
Text
id pubmed-3430019
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-34300192012-09-12 Acute phase reactant dynamics and incidence of microvascular dysfunctions in type 2 diabetes mellitus Azenabor, Alfred Ogbera, Anthonia O. Adejumo, Ngozi E. Adejare, Adejimi O. J Res Med Sci Original Article BACKGROUND: Acute Phase Reactants (APRs) have a wide range of activities that contribute to host defense. The aim of this report was to evaluate the dynamics and magnitude of these proteins in various microvascular complications in diabetes mellitus (DM). We also sought to assess the predictive values of APRs and other clinical variables for microvascular complications in DM. METHODS: This was a case control study carried out in 200 Nigerian subjects with type 2 DM and 100 sex and age matched healthy controls. The studied APRs included C-reactive protein, beta 2 microglobulin, fibrinogen and lipoprotein (a). RESULTS: The mean values of the APRs were significantly higher in type 2 DM compared with the controls and were observed in higher concentrations in those with microvascular complications, except beta 2 microglobulin. Presence of microvascular complications was observed in those with dilated fundus examination (retinopathy), symptom score of 3.0 (neuropathy), urea and creatinine levels above 50mg% and 1.5mg%, respectively, with significant proteinuria (nephropathy). Significant increase in mean ± SEM values of lipoprotein (a) was observed in diabetic retinopathy in comparison with those without complications (25.76 ± 1.13 mg/dl vs. 22.37 ± 0.73 mg/dl, p = 0.005). Elevated C-reactive protein was observed in diabetic neuropathy in comparison with those without complications (11.43 ± 2.33 u/ml vs. 8.30 ± 1.15 u/ml, p = 0.048). Increased beta 2 microglobulin levels were observed in patients with diabetic foot ulcers in comparison with those without complications (3.04 ± 0.51 mg/dl vs. 2.54 ± 0.14 mg/dl, p = 0.049). Circulating levels of Lipoprotein (a) predicted retinopathy in DM with both good and poor long-term glycemic control while duration of DM predicted the occurrence of foot ulcers.. CONCLUSIONS: Increased level of APRs was associated with a number of microvascular complications and may play a role in the pathogenesis. Medknow Publications & Media Pvt Ltd 2011-10 /pmc/articles/PMC3430019/ /pubmed/22973323 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Azenabor, Alfred
Ogbera, Anthonia O.
Adejumo, Ngozi E.
Adejare, Adejimi O.
Acute phase reactant dynamics and incidence of microvascular dysfunctions in type 2 diabetes mellitus
title Acute phase reactant dynamics and incidence of microvascular dysfunctions in type 2 diabetes mellitus
title_full Acute phase reactant dynamics and incidence of microvascular dysfunctions in type 2 diabetes mellitus
title_fullStr Acute phase reactant dynamics and incidence of microvascular dysfunctions in type 2 diabetes mellitus
title_full_unstemmed Acute phase reactant dynamics and incidence of microvascular dysfunctions in type 2 diabetes mellitus
title_short Acute phase reactant dynamics and incidence of microvascular dysfunctions in type 2 diabetes mellitus
title_sort acute phase reactant dynamics and incidence of microvascular dysfunctions in type 2 diabetes mellitus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430019/
https://www.ncbi.nlm.nih.gov/pubmed/22973323
work_keys_str_mv AT azenaboralfred acutephasereactantdynamicsandincidenceofmicrovasculardysfunctionsintype2diabetesmellitus
AT ogberaanthoniao acutephasereactantdynamicsandincidenceofmicrovasculardysfunctionsintype2diabetesmellitus
AT adejumongozie acutephasereactantdynamicsandincidenceofmicrovasculardysfunctionsintype2diabetesmellitus
AT adejareadejimio acutephasereactantdynamicsandincidenceofmicrovasculardysfunctionsintype2diabetesmellitus