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Comparison of prophylactic use of meperidine and two low doses of ketamine for prevention of post-anesthetic shivering: A randomized double-blind placebo controlled trial*

BACKGROUND: Postanesthetic shivering is one of the most common complications of anesthesia. We compared the efficacy of meperidine and two low doses of ketamine with placebo to prevent postanesthetic shivering after general anesthesia. METHODS: This was a prospective, randomized double-blind placebo...

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Autores principales: Ayatollahi, Vida, Hajiesmaeili, Mohammad Reza, Behdad, Shekoufeh, Gholipur, Mohammad, Abbasi, Hamid Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430025/
https://www.ncbi.nlm.nih.gov/pubmed/22973329
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author Ayatollahi, Vida
Hajiesmaeili, Mohammad Reza
Behdad, Shekoufeh
Gholipur, Mohammad
Abbasi, Hamid Reza
author_facet Ayatollahi, Vida
Hajiesmaeili, Mohammad Reza
Behdad, Shekoufeh
Gholipur, Mohammad
Abbasi, Hamid Reza
author_sort Ayatollahi, Vida
collection PubMed
description BACKGROUND: Postanesthetic shivering is one of the most common complications of anesthesia. We compared the efficacy of meperidine and two low doses of ketamine with placebo to prevent postanesthetic shivering after general anesthesia. METHODS: This was a prospective, randomized double-blind placebo controlled clinical trial involving 120 ASA I-II patients aging 20-50 years, undergoing endoscopic sinus surgery with general anesthesia. Patients were randomly allocated to receive meperidine 0.4 mg/kg (Group M, n = 30), ketamine 0.3 mg/kg (Group K(1), n = 30), ketamine 0.5 mg/kg (Group K(2), n = 30), or normal saline (Group N, n = 30) 20 minutes before completion of the surgery. Tympanic temperature, blood pressure, and heart rate were measured before and immediately after induction of anesthesia, 30 minutes after induction, and before administration of the study drugs. The drugs were prepared and diluted to a volume of 2 ml and presented as coded syringes. An investigator, blinded to the groups, graded postanesthetic shivering using a four-point scale. Statistical analyses were performed using Statistical Package for Social Sciences (SPSS) Windows version 16. A p-value < 0.05 was considered statistically significant. RESULTS: Patient characteristics of the four groups were similar. The number of patients with observed shivering in groups was 0, 3, 1, and 9 in Groups M, K(1), K(2) and N, respectively. The difference between groups M, K(1), and K(2) with Group N was statistically significant. However, differences between groups M and K(1), M and K(2), and K(1) and K(2) were not significant. The number of patients with a shivering score of 2 or 3 was higher in Group N compared with other groups. CONCLUSIONS: Prophylactic use of low doses of intravenous ketamine (0.3 or 0.5 mg/kg) was found to be effective to prevent postanesthetic shivering. However, administration of 0.3 mg/kg ketamine lowered the rate of hallucination as compared with 0.5 mg/kg.
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spelling pubmed-34300252012-09-12 Comparison of prophylactic use of meperidine and two low doses of ketamine for prevention of post-anesthetic shivering: A randomized double-blind placebo controlled trial* Ayatollahi, Vida Hajiesmaeili, Mohammad Reza Behdad, Shekoufeh Gholipur, Mohammad Abbasi, Hamid Reza J Res Med Sci Original Article BACKGROUND: Postanesthetic shivering is one of the most common complications of anesthesia. We compared the efficacy of meperidine and two low doses of ketamine with placebo to prevent postanesthetic shivering after general anesthesia. METHODS: This was a prospective, randomized double-blind placebo controlled clinical trial involving 120 ASA I-II patients aging 20-50 years, undergoing endoscopic sinus surgery with general anesthesia. Patients were randomly allocated to receive meperidine 0.4 mg/kg (Group M, n = 30), ketamine 0.3 mg/kg (Group K(1), n = 30), ketamine 0.5 mg/kg (Group K(2), n = 30), or normal saline (Group N, n = 30) 20 minutes before completion of the surgery. Tympanic temperature, blood pressure, and heart rate were measured before and immediately after induction of anesthesia, 30 minutes after induction, and before administration of the study drugs. The drugs were prepared and diluted to a volume of 2 ml and presented as coded syringes. An investigator, blinded to the groups, graded postanesthetic shivering using a four-point scale. Statistical analyses were performed using Statistical Package for Social Sciences (SPSS) Windows version 16. A p-value < 0.05 was considered statistically significant. RESULTS: Patient characteristics of the four groups were similar. The number of patients with observed shivering in groups was 0, 3, 1, and 9 in Groups M, K(1), K(2) and N, respectively. The difference between groups M, K(1), and K(2) with Group N was statistically significant. However, differences between groups M and K(1), M and K(2), and K(1) and K(2) were not significant. The number of patients with a shivering score of 2 or 3 was higher in Group N compared with other groups. CONCLUSIONS: Prophylactic use of low doses of intravenous ketamine (0.3 or 0.5 mg/kg) was found to be effective to prevent postanesthetic shivering. However, administration of 0.3 mg/kg ketamine lowered the rate of hallucination as compared with 0.5 mg/kg. Medknow Publications & Media Pvt Ltd 2011-10 /pmc/articles/PMC3430025/ /pubmed/22973329 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ayatollahi, Vida
Hajiesmaeili, Mohammad Reza
Behdad, Shekoufeh
Gholipur, Mohammad
Abbasi, Hamid Reza
Comparison of prophylactic use of meperidine and two low doses of ketamine for prevention of post-anesthetic shivering: A randomized double-blind placebo controlled trial*
title Comparison of prophylactic use of meperidine and two low doses of ketamine for prevention of post-anesthetic shivering: A randomized double-blind placebo controlled trial*
title_full Comparison of prophylactic use of meperidine and two low doses of ketamine for prevention of post-anesthetic shivering: A randomized double-blind placebo controlled trial*
title_fullStr Comparison of prophylactic use of meperidine and two low doses of ketamine for prevention of post-anesthetic shivering: A randomized double-blind placebo controlled trial*
title_full_unstemmed Comparison of prophylactic use of meperidine and two low doses of ketamine for prevention of post-anesthetic shivering: A randomized double-blind placebo controlled trial*
title_short Comparison of prophylactic use of meperidine and two low doses of ketamine for prevention of post-anesthetic shivering: A randomized double-blind placebo controlled trial*
title_sort comparison of prophylactic use of meperidine and two low doses of ketamine for prevention of post-anesthetic shivering: a randomized double-blind placebo controlled trial*
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430025/
https://www.ncbi.nlm.nih.gov/pubmed/22973329
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