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Relationship between echocardiographic findings and laboratory serum biomarkers in patients with and without low cardiac output
BACKGROUND: Cardiac dysfunction is seen in many patients and could be evaluated with echocardiography and serum biomarkers. The aim of this study was evaluation of the relationship between echocardiographic findings and laboratory serum biomarkers in children with and without low cardiac output. MET...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430055/ https://www.ncbi.nlm.nih.gov/pubmed/22973339 |
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author | Khalilian, Mohammad Reza Sabri, Mohammad Reza Nikyar, Abdolrasoul Javanmard, Shaghayegh Haghjooy |
author_facet | Khalilian, Mohammad Reza Sabri, Mohammad Reza Nikyar, Abdolrasoul Javanmard, Shaghayegh Haghjooy |
author_sort | Khalilian, Mohammad Reza |
collection | PubMed |
description | BACKGROUND: Cardiac dysfunction is seen in many patients and could be evaluated with echocardiography and serum biomarkers. The aim of this study was evaluation of the relationship between echocardiographic findings and laboratory serum biomarkers in children with and without low cardiac output. METHODS: Thirty patients older than 1 month with and without low cardiac output were enrolled in this study. It composed of 13 patients with dilated cardiomyopathy (DCM), 7 with end stage renal disease (ESRD) and 10 who had a Fontan operation. Echocardiography was performed with emphasis on shortening fraction (SF) and ejection fraction (EF). Blood samples were collected for measurement of atrial natriuretic peptide (ANP), high sensitivity C-reactive protein (hs-CRP) and alkaline phosphatase (Alk-P). Both echocardiographic findings and laboratory data were compared with control levels in twenty-seven normal children. Pearson correlation and regression analysis were conducted to evaluate the aforementioned associations. RESULTS: The mean of ANP and hs-CRP in the case group was statistically higher than control group (p < 0.001). The mean of ANP and hs-CRP were different in all groups (p < 0.001). There was a reverse linear regression between the SF and ANP in the case group (r = -0.594, p < 0.001). CONCLUSIONS: Determination of the plasma ANP and hs-CRP level may be helpful for decisions related to early diagnosis of patient with low cardiac output. |
format | Online Article Text |
id | pubmed-3430055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-34300552012-09-12 Relationship between echocardiographic findings and laboratory serum biomarkers in patients with and without low cardiac output Khalilian, Mohammad Reza Sabri, Mohammad Reza Nikyar, Abdolrasoul Javanmard, Shaghayegh Haghjooy J Res Med Sci Original Article BACKGROUND: Cardiac dysfunction is seen in many patients and could be evaluated with echocardiography and serum biomarkers. The aim of this study was evaluation of the relationship between echocardiographic findings and laboratory serum biomarkers in children with and without low cardiac output. METHODS: Thirty patients older than 1 month with and without low cardiac output were enrolled in this study. It composed of 13 patients with dilated cardiomyopathy (DCM), 7 with end stage renal disease (ESRD) and 10 who had a Fontan operation. Echocardiography was performed with emphasis on shortening fraction (SF) and ejection fraction (EF). Blood samples were collected for measurement of atrial natriuretic peptide (ANP), high sensitivity C-reactive protein (hs-CRP) and alkaline phosphatase (Alk-P). Both echocardiographic findings and laboratory data were compared with control levels in twenty-seven normal children. Pearson correlation and regression analysis were conducted to evaluate the aforementioned associations. RESULTS: The mean of ANP and hs-CRP in the case group was statistically higher than control group (p < 0.001). The mean of ANP and hs-CRP were different in all groups (p < 0.001). There was a reverse linear regression between the SF and ANP in the case group (r = -0.594, p < 0.001). CONCLUSIONS: Determination of the plasma ANP and hs-CRP level may be helpful for decisions related to early diagnosis of patient with low cardiac output. Medknow Publications & Media Pvt Ltd 2011-11 /pmc/articles/PMC3430055/ /pubmed/22973339 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Khalilian, Mohammad Reza Sabri, Mohammad Reza Nikyar, Abdolrasoul Javanmard, Shaghayegh Haghjooy Relationship between echocardiographic findings and laboratory serum biomarkers in patients with and without low cardiac output |
title | Relationship between echocardiographic findings and laboratory serum biomarkers in patients with and without low cardiac output |
title_full | Relationship between echocardiographic findings and laboratory serum biomarkers in patients with and without low cardiac output |
title_fullStr | Relationship between echocardiographic findings and laboratory serum biomarkers in patients with and without low cardiac output |
title_full_unstemmed | Relationship between echocardiographic findings and laboratory serum biomarkers in patients with and without low cardiac output |
title_short | Relationship between echocardiographic findings and laboratory serum biomarkers in patients with and without low cardiac output |
title_sort | relationship between echocardiographic findings and laboratory serum biomarkers in patients with and without low cardiac output |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430055/ https://www.ncbi.nlm.nih.gov/pubmed/22973339 |
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