The Tricyclodecan-9-yl-xanthogenate D609 Triggers Ceramide Increase and Enhances FasL-Induced Caspase-Dependent and -Independent Cell Death in T Lymphocytes

D609 is known to modulate death receptor-induced ceramide generation and cell death. We show that in Jurkat cells, non-toxic D609 concentrations inhibit sphingomyelin synthase and, to a lesser extent, glucosylceramide synthase, and transiently increase the intracellular ceramide level. D609 signific...

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Detalles Bibliográficos
Autores principales: Milhas, Delphine, Andrieu-Abadie, Nathalie, Levade, Thierry, Benoist, Hervé, Ségui, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430269/
https://www.ncbi.nlm.nih.gov/pubmed/22942738
http://dx.doi.org/10.3390/ijms13078834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430269/
https://www.ncbi.nlm.nih.gov/pubmed/22942738
http://dx.doi.org/10.3390/ijms13078834

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