Cargando…

Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL: A Potential Role for Macrophages in Trophoblast Apoptosis

Decidual macrophages (DM) are the second most abundant population in the fetal-maternal interface. Their role has been so far identified as being local immuno-modulators favoring the maternal tolerance to the fetus. Herein we investigated tissue samples from 11 cases of spontaneous miscarriages and...

Descripción completa

Detalles Bibliográficos
Autores principales: Guenther, Sabine, Vrekoussis, Thomas, Heublein, Sabine, Bayer, Birgit, Anz, David, Knabl, Julia, Navrozoglou, Iordanis, Dian, Darius, Friese, Klaus, Makrigiannakis, Antonis, Jeschke, Udo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430283/
https://www.ncbi.nlm.nih.gov/pubmed/22942752
http://dx.doi.org/10.3390/ijms13079069
_version_ 1782241928907063296
author Guenther, Sabine
Vrekoussis, Thomas
Heublein, Sabine
Bayer, Birgit
Anz, David
Knabl, Julia
Navrozoglou, Iordanis
Dian, Darius
Friese, Klaus
Makrigiannakis, Antonis
Jeschke, Udo
author_facet Guenther, Sabine
Vrekoussis, Thomas
Heublein, Sabine
Bayer, Birgit
Anz, David
Knabl, Julia
Navrozoglou, Iordanis
Dian, Darius
Friese, Klaus
Makrigiannakis, Antonis
Jeschke, Udo
author_sort Guenther, Sabine
collection PubMed
description Decidual macrophages (DM) are the second most abundant population in the fetal-maternal interface. Their role has been so far identified as being local immuno-modulators favoring the maternal tolerance to the fetus. Herein we investigated tissue samples from 11 cases of spontaneous miscarriages and from 9 cases of elective terminations of pregnancy. Using immunohistochemistry and dual immunofluorescence we have demonstrated that in spontaneous miscarriages the DM are significantly increased. Additionally, we noted a significant up-regulation of macrophage FasL expression. Our results further support a dual role for DM during pregnancy and miscarriages. We hypothesize that the baseline DM population in normal pregnancy is in line with an M2 phenotype supporting the ongoing gestation. In contrast, during spontaneous miscarriages, the increased FasL-expressing population could be a part of an M1 phenotype participating in Fas/FasL-related apoptosis. Our results highlight a new aspect of macrophage biology in pregnancy physiology and pathophysiology. Further studies with larger samples are needed to verify the current results and evaluate their clinical impact.
format Online
Article
Text
id pubmed-3430283
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-34302832012-08-31 Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL: A Potential Role for Macrophages in Trophoblast Apoptosis Guenther, Sabine Vrekoussis, Thomas Heublein, Sabine Bayer, Birgit Anz, David Knabl, Julia Navrozoglou, Iordanis Dian, Darius Friese, Klaus Makrigiannakis, Antonis Jeschke, Udo Int J Mol Sci Article Decidual macrophages (DM) are the second most abundant population in the fetal-maternal interface. Their role has been so far identified as being local immuno-modulators favoring the maternal tolerance to the fetus. Herein we investigated tissue samples from 11 cases of spontaneous miscarriages and from 9 cases of elective terminations of pregnancy. Using immunohistochemistry and dual immunofluorescence we have demonstrated that in spontaneous miscarriages the DM are significantly increased. Additionally, we noted a significant up-regulation of macrophage FasL expression. Our results further support a dual role for DM during pregnancy and miscarriages. We hypothesize that the baseline DM population in normal pregnancy is in line with an M2 phenotype supporting the ongoing gestation. In contrast, during spontaneous miscarriages, the increased FasL-expressing population could be a part of an M1 phenotype participating in Fas/FasL-related apoptosis. Our results highlight a new aspect of macrophage biology in pregnancy physiology and pathophysiology. Further studies with larger samples are needed to verify the current results and evaluate their clinical impact. Molecular Diversity Preservation International (MDPI) 2012-07-20 /pmc/articles/PMC3430283/ /pubmed/22942752 http://dx.doi.org/10.3390/ijms13079069 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Guenther, Sabine
Vrekoussis, Thomas
Heublein, Sabine
Bayer, Birgit
Anz, David
Knabl, Julia
Navrozoglou, Iordanis
Dian, Darius
Friese, Klaus
Makrigiannakis, Antonis
Jeschke, Udo
Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL: A Potential Role for Macrophages in Trophoblast Apoptosis
title Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL: A Potential Role for Macrophages in Trophoblast Apoptosis
title_full Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL: A Potential Role for Macrophages in Trophoblast Apoptosis
title_fullStr Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL: A Potential Role for Macrophages in Trophoblast Apoptosis
title_full_unstemmed Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL: A Potential Role for Macrophages in Trophoblast Apoptosis
title_short Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL: A Potential Role for Macrophages in Trophoblast Apoptosis
title_sort decidual macrophages are significantly increased in spontaneous miscarriages and over-express fasl: a potential role for macrophages in trophoblast apoptosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430283/
https://www.ncbi.nlm.nih.gov/pubmed/22942752
http://dx.doi.org/10.3390/ijms13079069
work_keys_str_mv AT guenthersabine decidualmacrophagesaresignificantlyincreasedinspontaneousmiscarriagesandoverexpressfaslapotentialroleformacrophagesintrophoblastapoptosis
AT vrekoussisthomas decidualmacrophagesaresignificantlyincreasedinspontaneousmiscarriagesandoverexpressfaslapotentialroleformacrophagesintrophoblastapoptosis
AT heubleinsabine decidualmacrophagesaresignificantlyincreasedinspontaneousmiscarriagesandoverexpressfaslapotentialroleformacrophagesintrophoblastapoptosis
AT bayerbirgit decidualmacrophagesaresignificantlyincreasedinspontaneousmiscarriagesandoverexpressfaslapotentialroleformacrophagesintrophoblastapoptosis
AT anzdavid decidualmacrophagesaresignificantlyincreasedinspontaneousmiscarriagesandoverexpressfaslapotentialroleformacrophagesintrophoblastapoptosis
AT knabljulia decidualmacrophagesaresignificantlyincreasedinspontaneousmiscarriagesandoverexpressfaslapotentialroleformacrophagesintrophoblastapoptosis
AT navrozoglouiordanis decidualmacrophagesaresignificantlyincreasedinspontaneousmiscarriagesandoverexpressfaslapotentialroleformacrophagesintrophoblastapoptosis
AT diandarius decidualmacrophagesaresignificantlyincreasedinspontaneousmiscarriagesandoverexpressfaslapotentialroleformacrophagesintrophoblastapoptosis
AT frieseklaus decidualmacrophagesaresignificantlyincreasedinspontaneousmiscarriagesandoverexpressfaslapotentialroleformacrophagesintrophoblastapoptosis
AT makrigiannakisantonis decidualmacrophagesaresignificantlyincreasedinspontaneousmiscarriagesandoverexpressfaslapotentialroleformacrophagesintrophoblastapoptosis
AT jeschkeudo decidualmacrophagesaresignificantlyincreasedinspontaneousmiscarriagesandoverexpressfaslapotentialroleformacrophagesintrophoblastapoptosis