Cargando…
Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL: A Potential Role for Macrophages in Trophoblast Apoptosis
Decidual macrophages (DM) are the second most abundant population in the fetal-maternal interface. Their role has been so far identified as being local immuno-modulators favoring the maternal tolerance to the fetus. Herein we investigated tissue samples from 11 cases of spontaneous miscarriages and...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430283/ https://www.ncbi.nlm.nih.gov/pubmed/22942752 http://dx.doi.org/10.3390/ijms13079069 |
_version_ | 1782241928907063296 |
---|---|
author | Guenther, Sabine Vrekoussis, Thomas Heublein, Sabine Bayer, Birgit Anz, David Knabl, Julia Navrozoglou, Iordanis Dian, Darius Friese, Klaus Makrigiannakis, Antonis Jeschke, Udo |
author_facet | Guenther, Sabine Vrekoussis, Thomas Heublein, Sabine Bayer, Birgit Anz, David Knabl, Julia Navrozoglou, Iordanis Dian, Darius Friese, Klaus Makrigiannakis, Antonis Jeschke, Udo |
author_sort | Guenther, Sabine |
collection | PubMed |
description | Decidual macrophages (DM) are the second most abundant population in the fetal-maternal interface. Their role has been so far identified as being local immuno-modulators favoring the maternal tolerance to the fetus. Herein we investigated tissue samples from 11 cases of spontaneous miscarriages and from 9 cases of elective terminations of pregnancy. Using immunohistochemistry and dual immunofluorescence we have demonstrated that in spontaneous miscarriages the DM are significantly increased. Additionally, we noted a significant up-regulation of macrophage FasL expression. Our results further support a dual role for DM during pregnancy and miscarriages. We hypothesize that the baseline DM population in normal pregnancy is in line with an M2 phenotype supporting the ongoing gestation. In contrast, during spontaneous miscarriages, the increased FasL-expressing population could be a part of an M1 phenotype participating in Fas/FasL-related apoptosis. Our results highlight a new aspect of macrophage biology in pregnancy physiology and pathophysiology. Further studies with larger samples are needed to verify the current results and evaluate their clinical impact. |
format | Online Article Text |
id | pubmed-3430283 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-34302832012-08-31 Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL: A Potential Role for Macrophages in Trophoblast Apoptosis Guenther, Sabine Vrekoussis, Thomas Heublein, Sabine Bayer, Birgit Anz, David Knabl, Julia Navrozoglou, Iordanis Dian, Darius Friese, Klaus Makrigiannakis, Antonis Jeschke, Udo Int J Mol Sci Article Decidual macrophages (DM) are the second most abundant population in the fetal-maternal interface. Their role has been so far identified as being local immuno-modulators favoring the maternal tolerance to the fetus. Herein we investigated tissue samples from 11 cases of spontaneous miscarriages and from 9 cases of elective terminations of pregnancy. Using immunohistochemistry and dual immunofluorescence we have demonstrated that in spontaneous miscarriages the DM are significantly increased. Additionally, we noted a significant up-regulation of macrophage FasL expression. Our results further support a dual role for DM during pregnancy and miscarriages. We hypothesize that the baseline DM population in normal pregnancy is in line with an M2 phenotype supporting the ongoing gestation. In contrast, during spontaneous miscarriages, the increased FasL-expressing population could be a part of an M1 phenotype participating in Fas/FasL-related apoptosis. Our results highlight a new aspect of macrophage biology in pregnancy physiology and pathophysiology. Further studies with larger samples are needed to verify the current results and evaluate their clinical impact. Molecular Diversity Preservation International (MDPI) 2012-07-20 /pmc/articles/PMC3430283/ /pubmed/22942752 http://dx.doi.org/10.3390/ijms13079069 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Guenther, Sabine Vrekoussis, Thomas Heublein, Sabine Bayer, Birgit Anz, David Knabl, Julia Navrozoglou, Iordanis Dian, Darius Friese, Klaus Makrigiannakis, Antonis Jeschke, Udo Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL: A Potential Role for Macrophages in Trophoblast Apoptosis |
title | Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL: A Potential Role for Macrophages in Trophoblast Apoptosis |
title_full | Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL: A Potential Role for Macrophages in Trophoblast Apoptosis |
title_fullStr | Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL: A Potential Role for Macrophages in Trophoblast Apoptosis |
title_full_unstemmed | Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL: A Potential Role for Macrophages in Trophoblast Apoptosis |
title_short | Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL: A Potential Role for Macrophages in Trophoblast Apoptosis |
title_sort | decidual macrophages are significantly increased in spontaneous miscarriages and over-express fasl: a potential role for macrophages in trophoblast apoptosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430283/ https://www.ncbi.nlm.nih.gov/pubmed/22942752 http://dx.doi.org/10.3390/ijms13079069 |
work_keys_str_mv | AT guenthersabine decidualmacrophagesaresignificantlyincreasedinspontaneousmiscarriagesandoverexpressfaslapotentialroleformacrophagesintrophoblastapoptosis AT vrekoussisthomas decidualmacrophagesaresignificantlyincreasedinspontaneousmiscarriagesandoverexpressfaslapotentialroleformacrophagesintrophoblastapoptosis AT heubleinsabine decidualmacrophagesaresignificantlyincreasedinspontaneousmiscarriagesandoverexpressfaslapotentialroleformacrophagesintrophoblastapoptosis AT bayerbirgit decidualmacrophagesaresignificantlyincreasedinspontaneousmiscarriagesandoverexpressfaslapotentialroleformacrophagesintrophoblastapoptosis AT anzdavid decidualmacrophagesaresignificantlyincreasedinspontaneousmiscarriagesandoverexpressfaslapotentialroleformacrophagesintrophoblastapoptosis AT knabljulia decidualmacrophagesaresignificantlyincreasedinspontaneousmiscarriagesandoverexpressfaslapotentialroleformacrophagesintrophoblastapoptosis AT navrozoglouiordanis decidualmacrophagesaresignificantlyincreasedinspontaneousmiscarriagesandoverexpressfaslapotentialroleformacrophagesintrophoblastapoptosis AT diandarius decidualmacrophagesaresignificantlyincreasedinspontaneousmiscarriagesandoverexpressfaslapotentialroleformacrophagesintrophoblastapoptosis AT frieseklaus decidualmacrophagesaresignificantlyincreasedinspontaneousmiscarriagesandoverexpressfaslapotentialroleformacrophagesintrophoblastapoptosis AT makrigiannakisantonis decidualmacrophagesaresignificantlyincreasedinspontaneousmiscarriagesandoverexpressfaslapotentialroleformacrophagesintrophoblastapoptosis AT jeschkeudo decidualmacrophagesaresignificantlyincreasedinspontaneousmiscarriagesandoverexpressfaslapotentialroleformacrophagesintrophoblastapoptosis |