Actions of a picomolar short-acting S1P(1) agonist in S1P(1)-eGFP knock-in mice

Sphingosine 1-Phosphate Receptor 1 (S1P(1)) plays a critical role in lymphocyte recirculation and is a clinical target for treatment of multiple sclerosis. By generating a short-duration S1P(1) agonist and mice where fluorescently tagged S1P(1) replaces wild-type receptor, we elucidate physiological...

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Autores principales: Cahalan, Stuart M., Gonzalez-Cabrera, Pedro J., Sarkisyan, Gor, Nguyen, Nhan, Schaeffer, Marie-Therese, Huang, Liming, Yeager, Adam, Clemons, Bryan, Scott, Fiona, Rosen, Hugh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430385/
https://www.ncbi.nlm.nih.gov/pubmed/21445057
http://dx.doi.org/10.1038/nchembio.547
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author Cahalan, Stuart M.
Gonzalez-Cabrera, Pedro J.
Sarkisyan, Gor
Nguyen, Nhan
Schaeffer, Marie-Therese
Huang, Liming
Yeager, Adam
Clemons, Bryan
Scott, Fiona
Rosen, Hugh
author_facet Cahalan, Stuart M.
Gonzalez-Cabrera, Pedro J.
Sarkisyan, Gor
Nguyen, Nhan
Schaeffer, Marie-Therese
Huang, Liming
Yeager, Adam
Clemons, Bryan
Scott, Fiona
Rosen, Hugh
author_sort Cahalan, Stuart M.
collection PubMed
description Sphingosine 1-Phosphate Receptor 1 (S1P(1)) plays a critical role in lymphocyte recirculation and is a clinical target for treatment of multiple sclerosis. By generating a short-duration S1P(1) agonist and mice where fluorescently tagged S1P(1) replaces wild-type receptor, we elucidate physiological and agonist-perturbed changes in expression of S1P(1) at a subcellular level in vivo. We demonstrate differential downregulation of S1P(1) on lymphocytes and endothelia following agonist treatment.
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spelling pubmed-34303852012-08-29 Actions of a picomolar short-acting S1P(1) agonist in S1P(1)-eGFP knock-in mice Cahalan, Stuart M. Gonzalez-Cabrera, Pedro J. Sarkisyan, Gor Nguyen, Nhan Schaeffer, Marie-Therese Huang, Liming Yeager, Adam Clemons, Bryan Scott, Fiona Rosen, Hugh Nat Chem Biol Article Sphingosine 1-Phosphate Receptor 1 (S1P(1)) plays a critical role in lymphocyte recirculation and is a clinical target for treatment of multiple sclerosis. By generating a short-duration S1P(1) agonist and mice where fluorescently tagged S1P(1) replaces wild-type receptor, we elucidate physiological and agonist-perturbed changes in expression of S1P(1) at a subcellular level in vivo. We demonstrate differential downregulation of S1P(1) on lymphocytes and endothelia following agonist treatment. 2011-03-27 2011-05 /pmc/articles/PMC3430385/ /pubmed/21445057 http://dx.doi.org/10.1038/nchembio.547 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Cahalan, Stuart M.
Gonzalez-Cabrera, Pedro J.
Sarkisyan, Gor
Nguyen, Nhan
Schaeffer, Marie-Therese
Huang, Liming
Yeager, Adam
Clemons, Bryan
Scott, Fiona
Rosen, Hugh
Actions of a picomolar short-acting S1P(1) agonist in S1P(1)-eGFP knock-in mice
title Actions of a picomolar short-acting S1P(1) agonist in S1P(1)-eGFP knock-in mice
title_full Actions of a picomolar short-acting S1P(1) agonist in S1P(1)-eGFP knock-in mice
title_fullStr Actions of a picomolar short-acting S1P(1) agonist in S1P(1)-eGFP knock-in mice
title_full_unstemmed Actions of a picomolar short-acting S1P(1) agonist in S1P(1)-eGFP knock-in mice
title_short Actions of a picomolar short-acting S1P(1) agonist in S1P(1)-eGFP knock-in mice
title_sort actions of a picomolar short-acting s1p(1) agonist in s1p(1)-egfp knock-in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430385/
https://www.ncbi.nlm.nih.gov/pubmed/21445057
http://dx.doi.org/10.1038/nchembio.547
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