Actions of a picomolar short-acting S1P(1) agonist in S1P(1)-eGFP knock-in mice

Sphingosine 1-Phosphate Receptor 1 (S1P(1)) plays a critical role in lymphocyte recirculation and is a clinical target for treatment of multiple sclerosis. By generating a short-duration S1P(1) agonist and mice where fluorescently tagged S1P(1) replaces wild-type receptor, we elucidate physiological...

Descripción completa

Detalles Bibliográficos
Autores principales: Cahalan, Stuart M., Gonzalez-Cabrera, Pedro J., Sarkisyan, Gor, Nguyen, Nhan, Schaeffer, Marie-Therese, Huang, Liming, Yeager, Adam, Clemons, Bryan, Scott, Fiona, Rosen, Hugh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430385/
https://www.ncbi.nlm.nih.gov/pubmed/21445057
http://dx.doi.org/10.1038/nchembio.547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430385/
https://www.ncbi.nlm.nih.gov/pubmed/21445057
http://dx.doi.org/10.1038/nchembio.547

Ejemplares similares