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Insulin receptor substrate-1 prevents autophagy-dependent cell death caused by oxidative stress in mouse NIH/3T3 cells

BACKGROUND: Insulin receptor substrate (IRS)-1 is associated with tumorigenesis; its levels are elevated in several human cancers. IRS-1 protein binds to several oncogene proteins. Oxidative stress and reactive oxygen species (ROS) are involved in the initiation and progression of cancers. Cancer ce...

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Detalles Bibliográficos
Autores principales:	Chan, Shih-Hung, Kikkawa, Ushio, Matsuzaki, Hidenori, Chen, Jyh-Hong, Chang, Wen-Chang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430578/ https://www.ncbi.nlm.nih.gov/pubmed/22788551 http://dx.doi.org/10.1186/1423-0127-19-64

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