Potent Neutralization of Botulinum Neurotoxin/B by Synergistic Action of Antibodies Recognizing Protein and Ganglioside Receptor Binding Domain

BACKGROUND: Botulinum neurotoxins (BoNTs), the causative agents for life-threatening human disease botulism, have been recognized as biological warfare agents. Monoclonal antibody (mAb) therapeutics hold considerable promise as BoNT therapeutics, but the potencies of mAbs against BoNTs are usually l...

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Detalles Bibliográficos
Autores principales: Chen, Changchun, Wang, Shuhui, Wang, Huajing, Mao, Xiaoyan, Zhang, Tiancheng, Ji, Guanghui, Shi, Xin, Xia, Tian, Lu, Weijia, Zhang, Dapeng, Dai, Jianxin, Guo, Yajun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430616/
https://www.ncbi.nlm.nih.gov/pubmed/22952786
http://dx.doi.org/10.1371/journal.pone.0043845

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