Vitamin K-Antagonists Accelerate Atherosclerotic Calcification and Induce a Vulnerable Plaque Phenotype

BACKGROUND: Vitamin K-antagonists (VKA) are treatment of choice and standard care for patients with venous thrombosis and thromboembolic risk. In experimental animal models as well as humans, VKA have been shown to promote medial elastocalcinosis. As vascular calcification is considered an independe...

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Detalles Bibliográficos
Autores principales: Schurgers, Leon J., Joosen, Ivo A., Laufer, Eduard M., Chatrou, Martijn L. L., Herfs, Marjolein, Winkens, Mark H. M., Westenfeld, Ralf, Veulemans, Verena, Krueger, Thilo, Shanahan, Catherine M., Jahnen-Dechent, Willi, Biessen, Erik, Narula, Jagat, Vermeer, Cees, Hofstra, Leonard, Reutelingsperger, Chris P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430691/
https://www.ncbi.nlm.nih.gov/pubmed/22952653
http://dx.doi.org/10.1371/journal.pone.0043229

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