Fenton Reaction Induced Cancer in Wild Type Rats Recapitulates Genomic Alterations Observed in Human Cancer

Iron overload has been associated with carcinogenesis in humans. Intraperitoneal administration of ferric nitrilotriacetate initiates a Fenton reaction in renal proximal tubules of rodents that ultimately leads to a high incidence of renal cell carcinoma (RCC) after repeated treatments. We performed...

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Detalles Bibliográficos
Autores principales: Akatsuka, Shinya, Yamashita, Yoriko, Ohara, Hiroki, Liu, Yu-Ting, Izumiya, Masashi, Abe, Koichiro, Ochiai, Masako, Jiang, Li, Nagai, Hirotaka, Okazaki, Yasumasa, Murakami, Hideki, Sekido, Yoshitaka, Arai, Eri, Kanai, Yae, Hino, Okio, Takahashi, Takashi, Nakagama, Hitoshi, Toyokuni, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430702/
https://www.ncbi.nlm.nih.gov/pubmed/22952676
http://dx.doi.org/10.1371/journal.pone.0043403

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