Non-lytic expulsion/exocytosis of Candida albicans from macrophages

Candida albicans is an opportunistic pathogen and is recognised and phagocytosed by macrophages. Using live-cell imaging, non-lytic expulsion/exocytosis of C. albicans from macrophages is demonstrated for the first time. Following complete expulsion, both the phagocyte and pathogen remain intact and...

Descripción completa

Detalles Bibliográficos
Autores principales: Bain, Judith M., Lewis, Leanne E., Okai, Blessing, Quinn, Janet, Gow, Neil A.R., Erwig, Lars-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2012
Materias:
Video Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430864/
https://www.ncbi.nlm.nih.gov/pubmed/22326419
http://dx.doi.org/10.1016/j.fgb.2012.01.008
Descripción
Sumario:Candida albicans is an opportunistic pathogen and is recognised and phagocytosed by macrophages. Using live-cell imaging, non-lytic expulsion/exocytosis of C. albicans from macrophages is demonstrated for the first time. Following complete expulsion, both the phagocyte and pathogen remain intact and viable. Partial engulfment of hyphal C. albicans without macrophage lysis is also demonstrated. These observations underpin the complexity of interactions between C. albicans and innate immune cells.

Ejemplares similares