Non-lytic expulsion/exocytosis of Candida albicans from macrophages

Candida albicans is an opportunistic pathogen and is recognised and phagocytosed by macrophages. Using live-cell imaging, non-lytic expulsion/exocytosis of C. albicans from macrophages is demonstrated for the first time. Following complete expulsion, both the phagocyte and pathogen remain intact and...

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Autores principales: Bain, Judith M., Lewis, Leanne E., Okai, Blessing, Quinn, Janet, Gow, Neil A.R., Erwig, Lars-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2012
Materias:
Video Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430864/
https://www.ncbi.nlm.nih.gov/pubmed/22326419
http://dx.doi.org/10.1016/j.fgb.2012.01.008
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author Bain, Judith M.
Lewis, Leanne E.
Okai, Blessing
Quinn, Janet
Gow, Neil A.R.
Erwig, Lars-Peter
author_facet Bain, Judith M.
Lewis, Leanne E.
Okai, Blessing
Quinn, Janet
Gow, Neil A.R.
Erwig, Lars-Peter
author_sort Bain, Judith M.
collection PubMed
description Candida albicans is an opportunistic pathogen and is recognised and phagocytosed by macrophages. Using live-cell imaging, non-lytic expulsion/exocytosis of C. albicans from macrophages is demonstrated for the first time. Following complete expulsion, both the phagocyte and pathogen remain intact and viable. Partial engulfment of hyphal C. albicans without macrophage lysis is also demonstrated. These observations underpin the complexity of interactions between C. albicans and innate immune cells.
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spelling pubmed-34308642012-09-05 Non-lytic expulsion/exocytosis of Candida albicans from macrophages Bain, Judith M. Lewis, Leanne E. Okai, Blessing Quinn, Janet Gow, Neil A.R. Erwig, Lars-Peter Fungal Genet Biol Video Article Candida albicans is an opportunistic pathogen and is recognised and phagocytosed by macrophages. Using live-cell imaging, non-lytic expulsion/exocytosis of C. albicans from macrophages is demonstrated for the first time. Following complete expulsion, both the phagocyte and pathogen remain intact and viable. Partial engulfment of hyphal C. albicans without macrophage lysis is also demonstrated. These observations underpin the complexity of interactions between C. albicans and innate immune cells. Academic Press 2012-09 /pmc/articles/PMC3430864/ /pubmed/22326419 http://dx.doi.org/10.1016/j.fgb.2012.01.008 Text en © 2012 Elsevier Inc. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Video Article
Bain, Judith M.
Lewis, Leanne E.
Okai, Blessing
Quinn, Janet
Gow, Neil A.R.
Erwig, Lars-Peter
Non-lytic expulsion/exocytosis of Candida albicans from macrophages
title Non-lytic expulsion/exocytosis of Candida albicans from macrophages
title_full Non-lytic expulsion/exocytosis of Candida albicans from macrophages
title_fullStr Non-lytic expulsion/exocytosis of Candida albicans from macrophages
title_full_unstemmed Non-lytic expulsion/exocytosis of Candida albicans from macrophages
title_short Non-lytic expulsion/exocytosis of Candida albicans from macrophages
title_sort non-lytic expulsion/exocytosis of candida albicans from macrophages
topic Video Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430864/
https://www.ncbi.nlm.nih.gov/pubmed/22326419
http://dx.doi.org/10.1016/j.fgb.2012.01.008
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