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Candida albicans infection inhibits macrophage cell division and proliferation
The pathogenicity of the opportunistic human fungal pathogen Candida albicans depends on its ability to inhibit effective destruction by host phagocytes. Using live cell video microscopy, we show here for the first time that C. albicans inhibits cell division in macrophages undergoing mitosis. Inhib...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academic Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430961/ https://www.ncbi.nlm.nih.gov/pubmed/22634272 http://dx.doi.org/10.1016/j.fgb.2012.05.007 |
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author | Lewis, Leanne E. Bain, Judith M. Lowes, Christina Gow, Neil A.R. Erwig, Lars-Peter |
author_facet | Lewis, Leanne E. Bain, Judith M. Lowes, Christina Gow, Neil A.R. Erwig, Lars-Peter |
author_sort | Lewis, Leanne E. |
collection | PubMed |
description | The pathogenicity of the opportunistic human fungal pathogen Candida albicans depends on its ability to inhibit effective destruction by host phagocytes. Using live cell video microscopy, we show here for the first time that C. albicans inhibits cell division in macrophages undergoing mitosis. Inhibition of macrophage cell division is dependent on the ability of C. albicans to form hyphae, as it is rarely observed following phagocytosis of UV-killed or morphogenesis-defective mutant Candida. Interestingly, failed cell division following phagocytosis of hyphal C. albicans is surprisingly common, and leads to the formation of large multinuclear macrophages. This raises question as to whether inhibition of macrophage cell division is another virulence attribute of C. albicans or enables host macrophages to contain the pathogen. |
format | Online Article Text |
id | pubmed-3430961 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Academic Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-34309612012-09-05 Candida albicans infection inhibits macrophage cell division and proliferation Lewis, Leanne E. Bain, Judith M. Lowes, Christina Gow, Neil A.R. Erwig, Lars-Peter Fungal Genet Biol Video Article The pathogenicity of the opportunistic human fungal pathogen Candida albicans depends on its ability to inhibit effective destruction by host phagocytes. Using live cell video microscopy, we show here for the first time that C. albicans inhibits cell division in macrophages undergoing mitosis. Inhibition of macrophage cell division is dependent on the ability of C. albicans to form hyphae, as it is rarely observed following phagocytosis of UV-killed or morphogenesis-defective mutant Candida. Interestingly, failed cell division following phagocytosis of hyphal C. albicans is surprisingly common, and leads to the formation of large multinuclear macrophages. This raises question as to whether inhibition of macrophage cell division is another virulence attribute of C. albicans or enables host macrophages to contain the pathogen. Academic Press 2012-09 /pmc/articles/PMC3430961/ /pubmed/22634272 http://dx.doi.org/10.1016/j.fgb.2012.05.007 Text en © 2012 Elsevier Inc. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license |
spellingShingle | Video Article Lewis, Leanne E. Bain, Judith M. Lowes, Christina Gow, Neil A.R. Erwig, Lars-Peter Candida albicans infection inhibits macrophage cell division and proliferation |
title | Candida albicans infection inhibits macrophage cell division and proliferation |
title_full | Candida albicans infection inhibits macrophage cell division and proliferation |
title_fullStr | Candida albicans infection inhibits macrophage cell division and proliferation |
title_full_unstemmed | Candida albicans infection inhibits macrophage cell division and proliferation |
title_short | Candida albicans infection inhibits macrophage cell division and proliferation |
title_sort | candida albicans infection inhibits macrophage cell division and proliferation |
topic | Video Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430961/ https://www.ncbi.nlm.nih.gov/pubmed/22634272 http://dx.doi.org/10.1016/j.fgb.2012.05.007 |
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