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Interferon Beta-1a Improves Urinary Symptoms, Reduces Proviral Load, and Modifies the Immune Response in a Patient with HAM/TSP
The human T-cell lymphotropic virus type 1 (HTLV-1) is the known causative agent of a chronic neurologic condition known as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Although several therapies have been evaluated for HAM/TSP, none have been approved for use in humans. In t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431060/ https://www.ncbi.nlm.nih.gov/pubmed/22953092 http://dx.doi.org/10.1155/2012/958786 |
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author | Costa, Davi Tanajura Sundberg, Michael Passos, Lúcia Muniz, André Luiz Santos, Silvane |
author_facet | Costa, Davi Tanajura Sundberg, Michael Passos, Lúcia Muniz, André Luiz Santos, Silvane |
author_sort | Costa, Davi Tanajura |
collection | PubMed |
description | The human T-cell lymphotropic virus type 1 (HTLV-1) is the known causative agent of a chronic neurologic condition known as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Although several therapies have been evaluated for HAM/TSP, none have been approved for use in humans. In this paper, we describe a 55-year-old female patient with HAM/TSP who was treated with interferon beta-1a. This patient, in comparison to 20 female patients with HAM/TSP who were not treated, showed improvement in urinary symptoms over four years of therapy, as well as a reduction in HTLV-1 proviral load and serum cytokine levels typically observed in HAM/TSP. This improved outcome merits further controlled studies on the use and efficacy of interferon beta-1a as a therapy for HAM/TSP. |
format | Online Article Text |
id | pubmed-3431060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34310602012-09-05 Interferon Beta-1a Improves Urinary Symptoms, Reduces Proviral Load, and Modifies the Immune Response in a Patient with HAM/TSP Costa, Davi Tanajura Sundberg, Michael Passos, Lúcia Muniz, André Luiz Santos, Silvane Case Rep Neurol Med Case Report The human T-cell lymphotropic virus type 1 (HTLV-1) is the known causative agent of a chronic neurologic condition known as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Although several therapies have been evaluated for HAM/TSP, none have been approved for use in humans. In this paper, we describe a 55-year-old female patient with HAM/TSP who was treated with interferon beta-1a. This patient, in comparison to 20 female patients with HAM/TSP who were not treated, showed improvement in urinary symptoms over four years of therapy, as well as a reduction in HTLV-1 proviral load and serum cytokine levels typically observed in HAM/TSP. This improved outcome merits further controlled studies on the use and efficacy of interferon beta-1a as a therapy for HAM/TSP. Hindawi Publishing Corporation 2012 2012-08-16 /pmc/articles/PMC3431060/ /pubmed/22953092 http://dx.doi.org/10.1155/2012/958786 Text en Copyright © 2012 Davi Tanajura Costa et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Costa, Davi Tanajura Sundberg, Michael Passos, Lúcia Muniz, André Luiz Santos, Silvane Interferon Beta-1a Improves Urinary Symptoms, Reduces Proviral Load, and Modifies the Immune Response in a Patient with HAM/TSP |
title | Interferon Beta-1a Improves Urinary Symptoms, Reduces Proviral
Load, and Modifies the Immune Response in a Patient with HAM/TSP |
title_full | Interferon Beta-1a Improves Urinary Symptoms, Reduces Proviral
Load, and Modifies the Immune Response in a Patient with HAM/TSP |
title_fullStr | Interferon Beta-1a Improves Urinary Symptoms, Reduces Proviral
Load, and Modifies the Immune Response in a Patient with HAM/TSP |
title_full_unstemmed | Interferon Beta-1a Improves Urinary Symptoms, Reduces Proviral
Load, and Modifies the Immune Response in a Patient with HAM/TSP |
title_short | Interferon Beta-1a Improves Urinary Symptoms, Reduces Proviral
Load, and Modifies the Immune Response in a Patient with HAM/TSP |
title_sort | interferon beta-1a improves urinary symptoms, reduces proviral
load, and modifies the immune response in a patient with ham/tsp |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431060/ https://www.ncbi.nlm.nih.gov/pubmed/22953092 http://dx.doi.org/10.1155/2012/958786 |
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