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Molecular Signature in HCV-Positive Lymphomas
Hepatitis C virus (HCV) is a positive, single-stranded RNA virus, which has been associated to different subtypes of B-cell non-Hodgkin lymphoma (B-NHL). Cumulative evidence suggests an HCV-related antigen driven process in the B-NHL development. The underlying molecular signature associated to HCV-...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431075/ https://www.ncbi.nlm.nih.gov/pubmed/22952554 http://dx.doi.org/10.1155/2012/623465 |
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author | De Re, Valli Caggiari, Laura Garziera, Marica De Zorzi, Mariangela Repetto, Ombretta |
author_facet | De Re, Valli Caggiari, Laura Garziera, Marica De Zorzi, Mariangela Repetto, Ombretta |
author_sort | De Re, Valli |
collection | PubMed |
description | Hepatitis C virus (HCV) is a positive, single-stranded RNA virus, which has been associated to different subtypes of B-cell non-Hodgkin lymphoma (B-NHL). Cumulative evidence suggests an HCV-related antigen driven process in the B-NHL development. The underlying molecular signature associated to HCV-related B-NHL has to date remained obscure. In this review, we discuss the recent developments in this field with a special mention to different sets of genes whose expression is associated with BCR coupled to Blys signaling which in turn was found to be linked to B-cell maturation stages and NF-κb transcription factor. Even if recent progress on HCV-B-NHL signature has been made, the precise relationship between HCV and lymphoma development and phenotype signature remain to be clarified. |
format | Online Article Text |
id | pubmed-3431075 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34310752012-09-05 Molecular Signature in HCV-Positive Lymphomas De Re, Valli Caggiari, Laura Garziera, Marica De Zorzi, Mariangela Repetto, Ombretta Clin Dev Immunol Review Article Hepatitis C virus (HCV) is a positive, single-stranded RNA virus, which has been associated to different subtypes of B-cell non-Hodgkin lymphoma (B-NHL). Cumulative evidence suggests an HCV-related antigen driven process in the B-NHL development. The underlying molecular signature associated to HCV-related B-NHL has to date remained obscure. In this review, we discuss the recent developments in this field with a special mention to different sets of genes whose expression is associated with BCR coupled to Blys signaling which in turn was found to be linked to B-cell maturation stages and NF-κb transcription factor. Even if recent progress on HCV-B-NHL signature has been made, the precise relationship between HCV and lymphoma development and phenotype signature remain to be clarified. Hindawi Publishing Corporation 2012 2012-08-16 /pmc/articles/PMC3431075/ /pubmed/22952554 http://dx.doi.org/10.1155/2012/623465 Text en Copyright © 2012 Valli De Re et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article De Re, Valli Caggiari, Laura Garziera, Marica De Zorzi, Mariangela Repetto, Ombretta Molecular Signature in HCV-Positive Lymphomas |
title | Molecular Signature in HCV-Positive Lymphomas |
title_full | Molecular Signature in HCV-Positive Lymphomas |
title_fullStr | Molecular Signature in HCV-Positive Lymphomas |
title_full_unstemmed | Molecular Signature in HCV-Positive Lymphomas |
title_short | Molecular Signature in HCV-Positive Lymphomas |
title_sort | molecular signature in hcv-positive lymphomas |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431075/ https://www.ncbi.nlm.nih.gov/pubmed/22952554 http://dx.doi.org/10.1155/2012/623465 |
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