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Molecular Signature in HCV-Positive Lymphomas

Hepatitis C virus (HCV) is a positive, single-stranded RNA virus, which has been associated to different subtypes of B-cell non-Hodgkin lymphoma (B-NHL). Cumulative evidence suggests an HCV-related antigen driven process in the B-NHL development. The underlying molecular signature associated to HCV-...

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Detalles Bibliográficos
Autores principales: De Re, Valli, Caggiari, Laura, Garziera, Marica, De Zorzi, Mariangela, Repetto, Ombretta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431075/
https://www.ncbi.nlm.nih.gov/pubmed/22952554
http://dx.doi.org/10.1155/2012/623465
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author De Re, Valli
Caggiari, Laura
Garziera, Marica
De Zorzi, Mariangela
Repetto, Ombretta
author_facet De Re, Valli
Caggiari, Laura
Garziera, Marica
De Zorzi, Mariangela
Repetto, Ombretta
author_sort De Re, Valli
collection PubMed
description Hepatitis C virus (HCV) is a positive, single-stranded RNA virus, which has been associated to different subtypes of B-cell non-Hodgkin lymphoma (B-NHL). Cumulative evidence suggests an HCV-related antigen driven process in the B-NHL development. The underlying molecular signature associated to HCV-related B-NHL has to date remained obscure. In this review, we discuss the recent developments in this field with a special mention to different sets of genes whose expression is associated with BCR coupled to Blys signaling which in turn was found to be linked to B-cell maturation stages and NF-κb transcription factor. Even if recent progress on HCV-B-NHL signature has been made, the precise relationship between HCV and lymphoma development and phenotype signature remain to be clarified.
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spelling pubmed-34310752012-09-05 Molecular Signature in HCV-Positive Lymphomas De Re, Valli Caggiari, Laura Garziera, Marica De Zorzi, Mariangela Repetto, Ombretta Clin Dev Immunol Review Article Hepatitis C virus (HCV) is a positive, single-stranded RNA virus, which has been associated to different subtypes of B-cell non-Hodgkin lymphoma (B-NHL). Cumulative evidence suggests an HCV-related antigen driven process in the B-NHL development. The underlying molecular signature associated to HCV-related B-NHL has to date remained obscure. In this review, we discuss the recent developments in this field with a special mention to different sets of genes whose expression is associated with BCR coupled to Blys signaling which in turn was found to be linked to B-cell maturation stages and NF-κb transcription factor. Even if recent progress on HCV-B-NHL signature has been made, the precise relationship between HCV and lymphoma development and phenotype signature remain to be clarified. Hindawi Publishing Corporation 2012 2012-08-16 /pmc/articles/PMC3431075/ /pubmed/22952554 http://dx.doi.org/10.1155/2012/623465 Text en Copyright © 2012 Valli De Re et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
De Re, Valli
Caggiari, Laura
Garziera, Marica
De Zorzi, Mariangela
Repetto, Ombretta
Molecular Signature in HCV-Positive Lymphomas
title Molecular Signature in HCV-Positive Lymphomas
title_full Molecular Signature in HCV-Positive Lymphomas
title_fullStr Molecular Signature in HCV-Positive Lymphomas
title_full_unstemmed Molecular Signature in HCV-Positive Lymphomas
title_short Molecular Signature in HCV-Positive Lymphomas
title_sort molecular signature in hcv-positive lymphomas
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431075/
https://www.ncbi.nlm.nih.gov/pubmed/22952554
http://dx.doi.org/10.1155/2012/623465
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