Efficient Hepatitis C Virus Particle Formation Requires Diacylglycerol Acyltransferase 1 (DGAT1)

Hepatitis C virus (HCV) infection is closely tied to the lipid metabolism of liver cells. Here, we identify the triglyceride-synthesizing enzyme DGAT1 as an important host factor for HCV infection; DGAT1 interacts with the viral nucleocapsid core and is required for the trafficking of core to lipid...

Descripción completa

Detalles Bibliográficos
Autores principales: Herker, Eva, Harris, Charles, Hernandez, Céline, Carpentier, Arnaud, Kaehlcke, Katrin, Rosenberg, Arielle R., Farese, Robert V., Ott, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431199/
https://www.ncbi.nlm.nih.gov/pubmed/20935628
http://dx.doi.org/10.1038/nm.2238
_version_ 1782242039030611968
author Herker, Eva
Harris, Charles
Hernandez, Céline
Carpentier, Arnaud
Kaehlcke, Katrin
Rosenberg, Arielle R.
Farese, Robert V.
Ott, Melanie
author_facet Herker, Eva
Harris, Charles
Hernandez, Céline
Carpentier, Arnaud
Kaehlcke, Katrin
Rosenberg, Arielle R.
Farese, Robert V.
Ott, Melanie
author_sort Herker, Eva
collection PubMed
description Hepatitis C virus (HCV) infection is closely tied to the lipid metabolism of liver cells. Here, we identify the triglyceride-synthesizing enzyme DGAT1 as an important host factor for HCV infection; DGAT1 interacts with the viral nucleocapsid core and is required for the trafficking of core to lipid droplets. Inhibition of DGAT1 activity or RNAi-mediated knockdown severely impairs infectious virion production, implicating DGAT1 as a new target for antiviral therapy.
format Online
Article
Text
id pubmed-3431199
institution National Center for Biotechnology Information
language English
publishDate 2010
record_format MEDLINE/PubMed
spelling pubmed-34311992012-08-30 Efficient Hepatitis C Virus Particle Formation Requires Diacylglycerol Acyltransferase 1 (DGAT1) Herker, Eva Harris, Charles Hernandez, Céline Carpentier, Arnaud Kaehlcke, Katrin Rosenberg, Arielle R. Farese, Robert V. Ott, Melanie Nat Med Article Hepatitis C virus (HCV) infection is closely tied to the lipid metabolism of liver cells. Here, we identify the triglyceride-synthesizing enzyme DGAT1 as an important host factor for HCV infection; DGAT1 interacts with the viral nucleocapsid core and is required for the trafficking of core to lipid droplets. Inhibition of DGAT1 activity or RNAi-mediated knockdown severely impairs infectious virion production, implicating DGAT1 as a new target for antiviral therapy. 2010-10-10 2010-11 /pmc/articles/PMC3431199/ /pubmed/20935628 http://dx.doi.org/10.1038/nm.2238 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Herker, Eva
Harris, Charles
Hernandez, Céline
Carpentier, Arnaud
Kaehlcke, Katrin
Rosenberg, Arielle R.
Farese, Robert V.
Ott, Melanie
Efficient Hepatitis C Virus Particle Formation Requires Diacylglycerol Acyltransferase 1 (DGAT1)
title Efficient Hepatitis C Virus Particle Formation Requires Diacylglycerol Acyltransferase 1 (DGAT1)
title_full Efficient Hepatitis C Virus Particle Formation Requires Diacylglycerol Acyltransferase 1 (DGAT1)
title_fullStr Efficient Hepatitis C Virus Particle Formation Requires Diacylglycerol Acyltransferase 1 (DGAT1)
title_full_unstemmed Efficient Hepatitis C Virus Particle Formation Requires Diacylglycerol Acyltransferase 1 (DGAT1)
title_short Efficient Hepatitis C Virus Particle Formation Requires Diacylglycerol Acyltransferase 1 (DGAT1)
title_sort efficient hepatitis c virus particle formation requires diacylglycerol acyltransferase 1 (dgat1)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431199/
https://www.ncbi.nlm.nih.gov/pubmed/20935628
http://dx.doi.org/10.1038/nm.2238
work_keys_str_mv AT herkereva efficienthepatitiscvirusparticleformationrequiresdiacylglycerolacyltransferase1dgat1
AT harrischarles efficienthepatitiscvirusparticleformationrequiresdiacylglycerolacyltransferase1dgat1
AT hernandezceline efficienthepatitiscvirusparticleformationrequiresdiacylglycerolacyltransferase1dgat1
AT carpentierarnaud efficienthepatitiscvirusparticleformationrequiresdiacylglycerolacyltransferase1dgat1
AT kaehlckekatrin efficienthepatitiscvirusparticleformationrequiresdiacylglycerolacyltransferase1dgat1
AT rosenbergarieller efficienthepatitiscvirusparticleformationrequiresdiacylglycerolacyltransferase1dgat1
AT fareserobertv efficienthepatitiscvirusparticleformationrequiresdiacylglycerolacyltransferase1dgat1
AT ottmelanie efficienthepatitiscvirusparticleformationrequiresdiacylglycerolacyltransferase1dgat1

Ejemplares similares