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Antidepressant Treatment Normalizes White Matter Volume in Patients with Major Depression
OBJECTIVE: To investigate white matter volume abnormalities in patients with major depression and the effects of antidepressant treatment on white matter volume. METHOD: Magnetic resonance imaging (MRI) was performed on 32 treatment-naïve depressed patients, 17 recovered patients who had received an...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431303/ https://www.ncbi.nlm.nih.gov/pubmed/22957005 http://dx.doi.org/10.1371/journal.pone.0044248 |
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author | Zeng, Ling-Li Liu, Li Liu, Yadong Shen, Hui Li, Yaming Hu, Dewen |
author_facet | Zeng, Ling-Li Liu, Li Liu, Yadong Shen, Hui Li, Yaming Hu, Dewen |
author_sort | Zeng, Ling-Li |
collection | PubMed |
description | OBJECTIVE: To investigate white matter volume abnormalities in patients with major depression and the effects of antidepressant treatment on white matter volume. METHOD: Magnetic resonance imaging (MRI) was performed on 32 treatment-naïve depressed patients, 17 recovered patients who had received antidepressant treatment and subsequently achieved clinical recovery and 34 matched controls. RESULTS: Relative to the healthy controls, the treatment-naïve depressed patients showed increased white matter volumes in the left dorsolateral prefrontal cortex (DLPFC) and left putamen and reduced white matter volumes in the left cerebellum posterior lobe and left inferior parietal lobule. For the treatment-naïve patients, the length in months of the current depressive episode was positively correlated with the white matter volumes in both the left DLPFC and left putamen. In the recovered patients, the differences in white matter volume were no longer statistically significant relative to healthy controls. No significant difference was found in the total white matter volume among the three groups. CONCLUSIONS: This study demonstrates that there were alterations in the white matter volumes of depressed patients, which might disrupt the neural circuits that are involved in emotional and cognitive function and thus contribute to the pathophysiology of depression. The finding of the significant correlations between refractoriness and the white matter volumes in the left DLPFC and left putamen combined with the finding that antidepressant treatment normalized the white matter volume of recovered patients, suggests that a quantitative, structural MRI measurement could act as a potential biomarker in depression therapy for individual subjects. |
format | Online Article Text |
id | pubmed-3431303 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-34313032012-09-06 Antidepressant Treatment Normalizes White Matter Volume in Patients with Major Depression Zeng, Ling-Li Liu, Li Liu, Yadong Shen, Hui Li, Yaming Hu, Dewen PLoS One Research Article OBJECTIVE: To investigate white matter volume abnormalities in patients with major depression and the effects of antidepressant treatment on white matter volume. METHOD: Magnetic resonance imaging (MRI) was performed on 32 treatment-naïve depressed patients, 17 recovered patients who had received antidepressant treatment and subsequently achieved clinical recovery and 34 matched controls. RESULTS: Relative to the healthy controls, the treatment-naïve depressed patients showed increased white matter volumes in the left dorsolateral prefrontal cortex (DLPFC) and left putamen and reduced white matter volumes in the left cerebellum posterior lobe and left inferior parietal lobule. For the treatment-naïve patients, the length in months of the current depressive episode was positively correlated with the white matter volumes in both the left DLPFC and left putamen. In the recovered patients, the differences in white matter volume were no longer statistically significant relative to healthy controls. No significant difference was found in the total white matter volume among the three groups. CONCLUSIONS: This study demonstrates that there were alterations in the white matter volumes of depressed patients, which might disrupt the neural circuits that are involved in emotional and cognitive function and thus contribute to the pathophysiology of depression. The finding of the significant correlations between refractoriness and the white matter volumes in the left DLPFC and left putamen combined with the finding that antidepressant treatment normalized the white matter volume of recovered patients, suggests that a quantitative, structural MRI measurement could act as a potential biomarker in depression therapy for individual subjects. Public Library of Science 2012-08-30 /pmc/articles/PMC3431303/ /pubmed/22957005 http://dx.doi.org/10.1371/journal.pone.0044248 Text en © 2012 Zeng et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Zeng, Ling-Li Liu, Li Liu, Yadong Shen, Hui Li, Yaming Hu, Dewen Antidepressant Treatment Normalizes White Matter Volume in Patients with Major Depression |
title | Antidepressant Treatment Normalizes White Matter Volume in Patients with Major Depression |
title_full | Antidepressant Treatment Normalizes White Matter Volume in Patients with Major Depression |
title_fullStr | Antidepressant Treatment Normalizes White Matter Volume in Patients with Major Depression |
title_full_unstemmed | Antidepressant Treatment Normalizes White Matter Volume in Patients with Major Depression |
title_short | Antidepressant Treatment Normalizes White Matter Volume in Patients with Major Depression |
title_sort | antidepressant treatment normalizes white matter volume in patients with major depression |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431303/ https://www.ncbi.nlm.nih.gov/pubmed/22957005 http://dx.doi.org/10.1371/journal.pone.0044248 |
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