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Complex Structure of Engineered Modular Domains Defining Molecular Interaction between ICAM-1 and Integrin LFA-1

Intermolecular contacts between integrin LFA-1 (α(L)β(2)) and ICAM-1 derive solely from the integrin α(L) I domain and the first domain (D1) of ICAM-1. This study presents a crystal structure of the engineered complex of the α(L) I domain and ICAM-1 D1. Previously, we engineered the I domain for hig...

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Detalles Bibliográficos
Autores principales:	Kang, Sungkwon, Kim, Chae Un, Gu, Xiaoling, Owens, Roisin M., van Rijn, Sarah J., Boonyaleepun, Vanissra, Mao, Yuxin, Springer, Timothy A., Jin, Moonsoo M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431320/ https://www.ncbi.nlm.nih.gov/pubmed/22956999 http://dx.doi.org/10.1371/journal.pone.0044124

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