Cargando…

The PICALM Protein Plays a Key Role in Iron Homeostasis and Cell Proliferation

The ubiquitously expressed phosphatidylinositol binding clathrin assembly (PICALM) protein associates with the plasma membrane, binds clathrin, and plays a role in clathrin-mediated endocytosis. Alterations of the human PICALM gene are present in aggressive hematopoietic malignancies, and genome-wid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Scotland, Paula B., Heath, Jessica L., Conway, Amanda E., Porter, Natasha B., Armstrong, Michael B., Walker, Jennifer A., Klebig, Mitchell L., Lavau, Catherine P., Wechsler, Daniel S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431333/ https://www.ncbi.nlm.nih.gov/pubmed/22952941 http://dx.doi.org/10.1371/journal.pone.0044252

Ejemplares similares

Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis
por: Mercer, Jacob L., et al.
Publicado: (2015)

PICALM modulates autophagy activity and tau accumulation
por: Moreau, Kevin, et al.
Publicado: (2014)

Corrigendum: PICALM modulates autophagy activity and tau accumulation
por: Moreau, Kevin, et al.
Publicado: (2015)

Iron Deprivation in Cancer––Potential Therapeutic Implications
por: Heath, Jessica L., et al.
Publicado: (2013)

An intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALM isoform
por: Parikh, Ishita, et al.
Publicado: (2014)

Association of Alzheimer’s disease risk variants on the PICALM gene with PICALM expression, core biomarkers, and feature neurodegeneration
por: Xu, Wei, et al.
Publicado: (2020)

Genetics of PICALM Expression and Alzheimer's Disease
por: Parikh, Ishita, et al.
Publicado: (2014)

PICALM and Alzheimer’s Disease: An Update and Perspectives
por: Ando, Kunie, et al.
Publicado: (2022)

Evidence that PICALM affects age at onset of Alzheimer's dementia in Down syndrome
por: Jones, Emma L., et al.
Publicado: (2013)

An Exploratory Study on CLU, CR1 and PICALM and Parkinson Disease
por: Gao, Jianjun, et al.
Publicado: (2011)

A Critical Role for CRM1 in Regulating HOXA Gene Transcription in CALM-AF10 Leukemias
por: Conway, Amanda E., et al.
Publicado: (2014)

Creation of a functional unc-11/PICALM GFP knock-in by CRISPR
por: Gallegos, Maria, et al.
Publicado: (2021)

A single codon insertion in PICALM is associated with development of familial subvalvular aortic stenosis in Newfoundland dogs
por: Stern, Joshua A., et al.
Publicado: (2014)

The Clathrin Assembly Protein PICALM Is Required for Erythroid Maturation and Transferrin Internalization in Mice
por: Suzuki, Mai, et al.
Publicado: (2012)

CLU, CR1 and PICALM genes associate with Alzheimer's-related senile plaques
por: Kok, Eloise H, et al.
Publicado: (2011)

The impact of PICALM genetic variations on reserve capacity of posterior cingulate in AD continuum
por: Xu, Wei, et al.
Publicado: (2016)

Central role for PICALM in amyloid–β blood–brain barrier transcytosis and clearance
por: Zhao, Zhen, et al.
Publicado: (2015)

PICALM mRNA Expression in the Blood of Patients with Neurodegenerative Diseases and Geriatric Depression
por: Kumon, Hiroshi, et al.
Publicado: (2021)

Decreasing the expression of PICALM reduces endocytosis and the activity of β-secretase: implications for Alzheimer’s disease
por: Thomas, Rhian S., et al.
Publicado: (2016)

Exosomal MicroRNA-155 Inhibits Enterovirus A71 Infection by Targeting PICALM
por: Wu, Jing, et al.
Publicado: (2019)

Influence of PICALM and CLU risk variants on beta EEG activity in Alzheimer’s disease patients
por: Maturana-Candelas, Aarón, et al.
Publicado: (2021)

A yeast model for amyloid-β aggregation exemplifies the role of membrane trafficking and PICALM in cytotoxicity
por: D’Angelo, Fabien, et al.
Publicado: (2013)

PICALM exerts a role in promoting CRC progression through ERK/MAPK signaling pathway
por: Zhang, Xitao, et al.
Publicado: (2022)

Key players in the regulation of iron homeostasis at the host-pathogen interface
por: Ullah, Inam, et al.
Publicado: (2023)

Dps Functions as a Key Player in Bacterial Iron Homeostasis
por: Williams, Sunanda Margrett, et al.
Publicado: (2023)

OsIRO3 Plays an Essential Role in Iron Deficiency Responses and Regulates Iron Homeostasis in Rice
por: Wang, Wujian, et al.
Publicado: (2020)

Gnpat does not play an essential role in systemic iron homeostasis in murine model
por: An, Peng, et al.
Publicado: (2020)

Abnormal iron homeostasis and neurodegeneration
por: Muhoberac, Barry B., et al.
Publicado: (2013)

Fusion of the CRM1 Nuclear Export Receptor to AF10 Causes Leukemia and Transcriptional Activation of HOXA Genes
por: Aumann, Waitman K., et al.
Publicado: (2020)

Inhibition of Aβ(42) oligomerization in yeast by a PICALM ortholog and certain FDA approved drugs
por: Park, Sei-Kyoung, et al.
Publicado: (2016)

Flt3 Does Not Play a Critical Role in Murine Myeloid Leukemias Induced by MLL Fusion Genes
por: Albouhair, Stéphanie, et al.
Publicado: (2013)

PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Aβ42 toxicity
por: Yu, Yifan, et al.
Publicado: (2020)

LncRNA CRNDE attenuates chemoresistance in gastric cancer via SRSF6-regulated alternative splicing of PICALM
por: Zhang, Feifei, et al.
Publicado: (2021)

PfsR Is a Key Regulator of Iron Homeostasis in Synechocystis PCC 6803
por: Cheng, Dan, et al.
Publicado: (2014)

Cytochrome P450 1B1: A Key Regulator of Ocular Iron Homeostasis and Oxidative Stress
por: Song, Yong-Seok, et al.
Publicado: (2022)

Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis
por: Core, Amanda B., et al.
Publicado: (2014)

The Interactive Effects of Age and PICALM rs541458 Polymorphism on Cognitive Performance, Brain Structure, and Function in Non-demented Elderly
por: Liu, Zhen, et al.
Publicado: (2017)

Genetic Variants of PICALM rs541458 Modulate Brain Spontaneous Activity in Older Adults With Amnestic Mild Cognitive Impairment
por: Zhuang, Liying, et al.
Publicado: (2019)

Genetic Association Between Alzheimer’s Disease Risk Variant of the PICALM Gene and EEG Functional Connectivity in Non-demented Adults
por: Ponomareva, Natalya, et al.
Publicado: (2020)

Circular RNA circPICALM sponges miR-1265 to inhibit bladder cancer metastasis and influence FAK phosphorylation
por: Yan, Dong, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_8e29ab4tq4ohdidpa72mnbdkgn