Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease–Related Tau Phosphorylation Via PAR-1

Abnormal phosphorylation and toxicity of a microtubule-associated protein tau are involved in the pathogenesis of Alzheimer's disease (AD); however, what pathological conditions trigger tau abnormality in AD is not fully understood. A reduction in the number of mitochondria in the axon has been...

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Detalles Bibliográficos
Autores principales: Iijima-Ando, Kanae, Sekiya, Michiko, Maruko-Otake, Akiko, Ohtake, Yosuke, Suzuki, Emiko, Lu, Bingwei, Iijima, Koichi M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431335/
https://www.ncbi.nlm.nih.gov/pubmed/22952452
http://dx.doi.org/10.1371/journal.pgen.1002918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431335/
https://www.ncbi.nlm.nih.gov/pubmed/22952452
http://dx.doi.org/10.1371/journal.pgen.1002918

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