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Reduced Prostasin (CAP1/PRSS8) Activity Eliminates HAI-1 and HAI-2 Deficiency–Associated Developmental Defects by Preventing Matriptase Activation

Loss of either hepatocyte growth factor activator inhibitor (HAI)-1 or -2 is associated with embryonic lethality in mice, which can be rescued by the simultaneous inactivation of the membrane-anchored serine protease, matriptase, thereby demonstrating that a matriptase-dependent proteolytic pathway...

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Detalles Bibliográficos
Autores principales:	Szabo, Roman, Uzzun Sales, Katiuchia, Kosa, Peter, Shylo, Natalia A., Godiksen, Sine, Hansen, Karina K., Friis, Stine, Gutkind, J. Silvio, Vogel, Lotte K., Hummler, Edith, Camerer, Eric, Bugge, Thomas H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431340/ https://www.ncbi.nlm.nih.gov/pubmed/22952456 http://dx.doi.org/10.1371/journal.pgen.1002937

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