Structure of the Nuclear Factor κB-inducing Kinase (NIK) Kinase Domain Reveals a Constitutively Active Conformation

NF-κB-inducing kinase (NIK) is a central component in the non-canonical NF-κB signaling pathway. Excessive NIK activity is implicated in various disorders, such as autoimmune conditions and cancers. Here, we report the first crystal structure of truncated human NIK in complex with adenosine 5′-O-(th...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Jinsong, Sudom, Athena, Min, Xiaoshan, Cao, Zhaodan, Gao, Xiong, Ayres, Merrill, Lee, Fei, Cao, Ping, Johnstone, Sheree, Plotnikova, Olga, Walker, Nigel, Chen, Guoqing, Wang, Zhulun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431628/
https://www.ncbi.nlm.nih.gov/pubmed/22718757
http://dx.doi.org/10.1074/jbc.M112.366658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431628/
https://www.ncbi.nlm.nih.gov/pubmed/22718757
http://dx.doi.org/10.1074/jbc.M112.366658

Ejemplares similares