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Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils: IMPLICATIONS FOR CANCER
Over 50% of all human cancers lose p53 function. To evaluate the role of aggregation in cancer, we asked whether wild-type (WT) p53 and the hot-spot mutant R248Q could aggregate as amyloids under physiological conditions and whether the mutant could seed aggregation of the wild-type form. The centra...
Autores principales: | Ano Bom, Ana P. D., Rangel, Luciana P., Costa, Danielly C. F., de Oliveira, Guilherme A. P., Sanches, Daniel, Braga, Carolina A., Gava, Lisandra M., Ramos, Carlos H. I., Cepeda, Ana O. T., Stumbo, Ana C., De Moura Gallo, Claudia V., Cordeiro, Yraima, Silva, Jerson L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431633/ https://www.ncbi.nlm.nih.gov/pubmed/22715097 http://dx.doi.org/10.1074/jbc.M112.340638 |
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