Cargando…

The Human Transporter Associated with Antigen Processing: MOLECULAR MODELS TO DESCRIBE PEPTIDE BINDING COMPETENT STATES

The human transporter associated with antigen processing (TAP) is a member of the ATP binding cassette (ABC) transporter superfamily. TAP plays an essential role in the antigen presentation pathway by translocating cytosolic peptides derived from proteasomal degradation into the endoplasmic reticulu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Corradi, Valentina, Singh, Gurpreet, Tieleman, D. Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Membrane Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431710/ https://www.ncbi.nlm.nih.gov/pubmed/22700967 http://dx.doi.org/10.1074/jbc.M112.381251

Ejemplares similares

Composition Fluctuations in Lipid Bilayers
por: Baoukina, Svetlana, et al.
Publicado: (2017)

Tripartite ATP-independent Periplasmic (TRAP) Transporters Use an Arginine-mediated Selectivity Filter for High Affinity Substrate Binding
por: Fischer, Marcus, et al.
Publicado: (2015)

Unraveling the structural elements of pH sensitivity and substrate binding in the human zinc transporter SLC39A2 (ZIP2)
por: Gyimesi, Gergely, et al.
Publicado: (2019)

Processive ATP-driven Substrate Disassembly by the N-Ethylmaleimide-sensitive Factor (NSF) Molecular Machine
por: Cipriano, Daniel J., et al.
Publicado: (2013)

A Glucose Transporter Can Mediate Ribose Uptake: DEFINITION OF RESIDUES THAT CONFER SUBSTRATE SPECIFICITY IN A SUGAR TRANSPORTER
por: Naula, Christina M., et al.
Publicado: (2010)

Uroplakins Do Not Restrict CO(2) Transport through Urothelium
por: Zocher, Florian, et al.
Publicado: (2012)

Mammalian Glucose Transporter Activity Is Dependent upon Anionic and Conical Phospholipids
por: Hresko, Richard C., et al.
Publicado: (2016)

Substituted cysteine accessibility method (SCAM) analysis of the transport domain of human concentrative nucleoside transporter 3 (hCNT3) and other family members reveals features of structural and functional importance
por: Mulinta, Ras, et al.
Publicado: (2017)

Synergism of Antimicrobial Frog Peptides Couples to Membrane Intrinsic Curvature Strain
por: Leber, Regina, et al.
Publicado: (2018)

The Bacterial Translocon SecYEG Opens upon Ribosome Binding
por: Knyazev, Denis G., et al.
Publicado: (2013)

PE and PS Lipids Synergistically Enhance Membrane Poration by a Peptide with Anticancer Properties
por: Leite, Natália Bueno, et al.
Publicado: (2015)

Conformational Flexibility Determines Selectivity and Antibacterial, Antiplasmodial, and Anticancer Potency of Cationic α-Helical Peptides
por: Vermeer, Louic S., et al.
Publicado: (2012)

Design and development of stapled transmembrane peptides that disrupt the activity of G-protein–coupled receptor oligomers
por: Botta, Joaquín, et al.
Publicado: (2019)

A Role for Weak Electrostatic Interactions in Peripheral Membrane Protein Binding
por: Khan, Hanif M., et al.
Publicado: (2016)

Plant-Specific Cation/H(+) Exchanger 17 and Its Homologs Are Endomembrane K(+) Transporters with Roles in Protein Sorting
por: Chanroj, Salil, et al.
Publicado: (2011)

Structure and Function of the Bacterial Heterodimeric ABC Transporter CydDC: STIMULATION OF ATPASE ACTIVITY BY THIOL AND HEME COMPOUNDS
por: Yamashita, Masao, et al.
Publicado: (2014)

Ligand-specific conformational transitions and intracellular transport are required for atypical chemokine receptor 3–mediated chemokine scavenging
por: Montpas, Nicolas, et al.
Publicado: (2018)

Substrate recognition and ATPase activity of the E. coli cysteine/cystine ABC transporter YecSC-FliY
por: Sabrialabed, Siwar, et al.
Publicado: (2020)

Mapping the Binding Site of the Inhibitor Tariquidar That Stabilizes the First Transmembrane Domain of P-glycoprotein
por: Loo, Tip W., et al.
Publicado: (2015)

The Oligomeric State and Arrangement of the Active Bacterial Translocon
por: Deville, Karine, et al.
Publicado: (2011)

β-Subunit Binding Is Sufficient for Ligands to Open the Integrin α(IIb)β(3) Headpiece
por: Lin, Fu-Yang, et al.
Publicado: (2016)

Dopamine transporter forms stable dimers in the live cell plasma membrane in a phosphatidylinositol 4,5-bisphosphate–independent manner
por: Das, Anand Kant, et al.
Publicado: (2019)

Molecular Determinants of Phospholipid Synergy in Blood Clotting
por: Tavoosi, Narjes, et al.
Publicado: (2011)

Solvent accessibility changes in a Na(+)-dependent C(4)-dicarboxylate transporter suggest differential substrate effects in a multistep mechanism
por: Sampson, Connor D.D., et al.
Publicado: (2021)

The Oligomeric States of the Purified Sigma-1 Receptor Are Stabilized by Ligands
por: Gromek, Katarzyna A., et al.
Publicado: (2014)

AS160 Phosphotyrosine-binding Domain Constructs Inhibit Insulin-stimulated GLUT4 Vesicle Fusion with the Plasma Membrane
por: Koumanov, Françoise, et al.
Publicado: (2011)

Multisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia chrysanthemi Ligand-gated Ion Channel (ELIC)
por: Spurny, Radovan, et al.
Publicado: (2013)

PA1b Inhibitor Binding to Subunits c and e of the Vacuolar ATPase Reveals Its Insecticidal Mechanism
por: Muench, Stephen P., et al.
Publicado: (2014)

Identification of the Bombyx Red Egg Gene Reveals Involvement of a Novel Transporter Family Gene in Late Steps of the Insect Ommochrome Biosynthesis Pathway
por: Osanai-Futahashi, Mizuko, et al.
Publicado: (2012)

State-dependent Inhibition of TRPM2 Channel by Acidic pH
por: Yang, Wei, et al.
Publicado: (2010)

Dual Conserved Periplasmic Loops Possess Essential Charge Characteristics That Support a Catch-and-Release Mechanism of O-antigen Polymerization by Wzy in Pseudomonas aeruginosa PAO1
por: Islam, Salim T., et al.
Publicado: (2011)

Role of Binding and Nucleoside Diphosphate Kinase A in the Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator by AMP-activated Protein Kinase
por: King, J Darwin, et al.
Publicado: (2012)

Interactions of Cations with the Cytoplasmic Pores of Inward Rectifier K(+) Channels in the Closed State
por: Inanobe, Atsushi, et al.
Publicado: (2011)

Molecular Mechanism of Lipid Nanodisk Formation by Styrene-Maleic Acid Copolymers
por: Xue, Minmin, et al.
Publicado: (2018)

Vesicle-associated Membrane Protein 3 (VAMP3) Mediates Constitutive Trafficking of the Renal Co-transporter NKCC2 in Thick Ascending Limbs: ROLE IN RENAL FUNCTION AND BLOOD PRESSURE
por: Caceres, Paulo S., et al.
Publicado: (2016)

Crystal Structures of the L(1), L(2), N, and O States of pharaonis Halorhodopsin
por: Kouyama, Tsutomu, et al.
Publicado: (2015)

A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-gated Ca(V)1.2 Calcium Channel Function
por: Kaur, Gurjot, et al.
Publicado: (2015)

Molecular Mechanism Underlying Phosphatidylinositol 4,5-Bisphosphate-induced Inhibition of SpIH Channels
por: Flynn, Galen E., et al.
Publicado: (2011)

Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain
por: Lörinczi, Eva, et al.
Publicado: (2016)

Munc18-1 Protein Molecules Move between Membrane Molecular Depots Distinct from Vesicle Docking Sites
por: Smyth, Annya M., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_h012vd6ujrtojdpgg0en3s2hsj