The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion

The pancreatic ductal adenocarcinoma (PDAC) microenvironment accommodates a variety of cell types and a plethora of complex interactions between tumor cells, host cells and extracellular matrix (ECM) components. Here we review the role of inflammatory cells, in particular mast cells, myeloid-derived...

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Detalles Bibliográficos
Autores principales: Evans, Anthony, Costello, Eithne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431795/
https://www.ncbi.nlm.nih.gov/pubmed/22969725
http://dx.doi.org/10.3389/fphys.2012.00270
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author Evans, Anthony
Costello, Eithne
author_facet Evans, Anthony
Costello, Eithne
author_sort Evans, Anthony
collection PubMed
description The pancreatic ductal adenocarcinoma (PDAC) microenvironment accommodates a variety of cell types and a plethora of complex interactions between tumor cells, host cells and extracellular matrix (ECM) components. Here we review the role of inflammatory cells, in particular mast cells, myeloid-derived suppressor cells, macrophages, T regulatory cells, T helper cells and neutrophils. The picture that emerges is that of a tumor microenvironment, in which the immune response is actively suppressed, and inflammatory cells contribute in a variety of ways to tumor progression.
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spelling pubmed-34317952012-09-11 The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion Evans, Anthony Costello, Eithne Front Physiol Physiology The pancreatic ductal adenocarcinoma (PDAC) microenvironment accommodates a variety of cell types and a plethora of complex interactions between tumor cells, host cells and extracellular matrix (ECM) components. Here we review the role of inflammatory cells, in particular mast cells, myeloid-derived suppressor cells, macrophages, T regulatory cells, T helper cells and neutrophils. The picture that emerges is that of a tumor microenvironment, in which the immune response is actively suppressed, and inflammatory cells contribute in a variety of ways to tumor progression. Frontiers Media S.A. 2012-07-13 /pmc/articles/PMC3431795/ /pubmed/22969725 http://dx.doi.org/10.3389/fphys.2012.00270 Text en Copyright © 2012 Evans and Costello. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Physiology
Evans, Anthony
Costello, Eithne
The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion
title The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion
title_full The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion
title_fullStr The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion
title_full_unstemmed The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion
title_short The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion
title_sort role of inflammatory cells in fostering pancreatic cancer cell growth and invasion
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431795/
https://www.ncbi.nlm.nih.gov/pubmed/22969725
http://dx.doi.org/10.3389/fphys.2012.00270
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