Bone Marrow-Derived HipOP Cell Population Is Markedly Enriched in Osteoprogenitors

We recently succeeded in purifying a novel multipotential progenitor or stem cell population from bone marrow stromal cells (BMSCs). This population exhibited a very high frequency of colony forming units-osteoblast (CFU-O; 100 times higher than in BMSCs) and high expression levels of osteoblast dif...

Descripción completa

Detalles Bibliográficos
Autores principales: Itoh, Shousaku, Matsushita, Kenta, Ikeda, Shun, Yamamoto, Yumiko, Yamauchi, Yukako, Yoshioka, Seisuke, Yamamoto, Reiko, Ebisu, Shigeyuki, Hayashi, Mikako, Aubin, Jane E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431855/
https://www.ncbi.nlm.nih.gov/pubmed/22949857
http://dx.doi.org/10.3390/ijms130810229
Descripción
Sumario:We recently succeeded in purifying a novel multipotential progenitor or stem cell population from bone marrow stromal cells (BMSCs). This population exhibited a very high frequency of colony forming units-osteoblast (CFU-O; 100 times higher than in BMSCs) and high expression levels of osteoblast differentiation markers. Furthermore, large masses of mineralized tissue were observed in in vivo transplants with this new population, designated highly purified osteoprogenitors (HipOPs). We now report the detailed presence and localization of HipOPs and recipient cells in transplants, and demonstrate that there is a strong relationship between the mineralized tissue volume formed and the transplanted number of HipOPs.

Ejemplares similares