Bone Marrow-Derived HipOP Cell Population Is Markedly Enriched in Osteoprogenitors

We recently succeeded in purifying a novel multipotential progenitor or stem cell population from bone marrow stromal cells (BMSCs). This population exhibited a very high frequency of colony forming units-osteoblast (CFU-O; 100 times higher than in BMSCs) and high expression levels of osteoblast dif...

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Autores principales: Itoh, Shousaku, Matsushita, Kenta, Ikeda, Shun, Yamamoto, Yumiko, Yamauchi, Yukako, Yoshioka, Seisuke, Yamamoto, Reiko, Ebisu, Shigeyuki, Hayashi, Mikako, Aubin, Jane E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431855/
https://www.ncbi.nlm.nih.gov/pubmed/22949857
http://dx.doi.org/10.3390/ijms130810229
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author Itoh, Shousaku
Matsushita, Kenta
Ikeda, Shun
Yamamoto, Yumiko
Yamauchi, Yukako
Yoshioka, Seisuke
Yamamoto, Reiko
Ebisu, Shigeyuki
Hayashi, Mikako
Aubin, Jane E.
author_facet Itoh, Shousaku
Matsushita, Kenta
Ikeda, Shun
Yamamoto, Yumiko
Yamauchi, Yukako
Yoshioka, Seisuke
Yamamoto, Reiko
Ebisu, Shigeyuki
Hayashi, Mikako
Aubin, Jane E.
author_sort Itoh, Shousaku
collection PubMed
description We recently succeeded in purifying a novel multipotential progenitor or stem cell population from bone marrow stromal cells (BMSCs). This population exhibited a very high frequency of colony forming units-osteoblast (CFU-O; 100 times higher than in BMSCs) and high expression levels of osteoblast differentiation markers. Furthermore, large masses of mineralized tissue were observed in in vivo transplants with this new population, designated highly purified osteoprogenitors (HipOPs). We now report the detailed presence and localization of HipOPs and recipient cells in transplants, and demonstrate that there is a strong relationship between the mineralized tissue volume formed and the transplanted number of HipOPs.
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spelling pubmed-34318552012-09-04 Bone Marrow-Derived HipOP Cell Population Is Markedly Enriched in Osteoprogenitors Itoh, Shousaku Matsushita, Kenta Ikeda, Shun Yamamoto, Yumiko Yamauchi, Yukako Yoshioka, Seisuke Yamamoto, Reiko Ebisu, Shigeyuki Hayashi, Mikako Aubin, Jane E. Int J Mol Sci Article We recently succeeded in purifying a novel multipotential progenitor or stem cell population from bone marrow stromal cells (BMSCs). This population exhibited a very high frequency of colony forming units-osteoblast (CFU-O; 100 times higher than in BMSCs) and high expression levels of osteoblast differentiation markers. Furthermore, large masses of mineralized tissue were observed in in vivo transplants with this new population, designated highly purified osteoprogenitors (HipOPs). We now report the detailed presence and localization of HipOPs and recipient cells in transplants, and demonstrate that there is a strong relationship between the mineralized tissue volume formed and the transplanted number of HipOPs. Molecular Diversity Preservation International (MDPI) 2012-08-16 /pmc/articles/PMC3431855/ /pubmed/22949857 http://dx.doi.org/10.3390/ijms130810229 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Itoh, Shousaku
Matsushita, Kenta
Ikeda, Shun
Yamamoto, Yumiko
Yamauchi, Yukako
Yoshioka, Seisuke
Yamamoto, Reiko
Ebisu, Shigeyuki
Hayashi, Mikako
Aubin, Jane E.
Bone Marrow-Derived HipOP Cell Population Is Markedly Enriched in Osteoprogenitors
title Bone Marrow-Derived HipOP Cell Population Is Markedly Enriched in Osteoprogenitors
title_full Bone Marrow-Derived HipOP Cell Population Is Markedly Enriched in Osteoprogenitors
title_fullStr Bone Marrow-Derived HipOP Cell Population Is Markedly Enriched in Osteoprogenitors
title_full_unstemmed Bone Marrow-Derived HipOP Cell Population Is Markedly Enriched in Osteoprogenitors
title_short Bone Marrow-Derived HipOP Cell Population Is Markedly Enriched in Osteoprogenitors
title_sort bone marrow-derived hipop cell population is markedly enriched in osteoprogenitors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431855/
https://www.ncbi.nlm.nih.gov/pubmed/22949857
http://dx.doi.org/10.3390/ijms130810229
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