Melanogenesis Inhibition by Homoisoflavavone Sappanone A from Caesalpinia sappan

Homoisoflavanone, sappanone A, was isolated from Caesalpinia sappan and proven to dose-dependently inhibit both melanogenesis and cellular tyrosinase activity via repressing tyrosinase gene expression in mouse B16 melanoma cells. To our knowledge, sappanone A is the first homoisoflavanone to be disc...

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Autores principales: Chang, Te-Sheng, Chao, Shih-Yu, Ding, Hsiou-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431864/
https://www.ncbi.nlm.nih.gov/pubmed/22949866
http://dx.doi.org/10.3390/ijms130810359
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author Chang, Te-Sheng
Chao, Shih-Yu
Ding, Hsiou-Yu
author_facet Chang, Te-Sheng
Chao, Shih-Yu
Ding, Hsiou-Yu
author_sort Chang, Te-Sheng
collection PubMed
description Homoisoflavanone, sappanone A, was isolated from Caesalpinia sappan and proven to dose-dependently inhibit both melanogenesis and cellular tyrosinase activity via repressing tyrosinase gene expression in mouse B16 melanoma cells. To our knowledge, sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. Our results give a new impetus to the future search for other homoisoflavanone melanogenesis inhibitors.
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spelling pubmed-34318642012-09-04 Melanogenesis Inhibition by Homoisoflavavone Sappanone A from Caesalpinia sappan Chang, Te-Sheng Chao, Shih-Yu Ding, Hsiou-Yu Int J Mol Sci Article Homoisoflavanone, sappanone A, was isolated from Caesalpinia sappan and proven to dose-dependently inhibit both melanogenesis and cellular tyrosinase activity via repressing tyrosinase gene expression in mouse B16 melanoma cells. To our knowledge, sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. Our results give a new impetus to the future search for other homoisoflavanone melanogenesis inhibitors. Molecular Diversity Preservation International (MDPI) 2012-08-20 /pmc/articles/PMC3431864/ /pubmed/22949866 http://dx.doi.org/10.3390/ijms130810359 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Chang, Te-Sheng
Chao, Shih-Yu
Ding, Hsiou-Yu
Melanogenesis Inhibition by Homoisoflavavone Sappanone A from Caesalpinia sappan
title Melanogenesis Inhibition by Homoisoflavavone Sappanone A from Caesalpinia sappan
title_full Melanogenesis Inhibition by Homoisoflavavone Sappanone A from Caesalpinia sappan
title_fullStr Melanogenesis Inhibition by Homoisoflavavone Sappanone A from Caesalpinia sappan
title_full_unstemmed Melanogenesis Inhibition by Homoisoflavavone Sappanone A from Caesalpinia sappan
title_short Melanogenesis Inhibition by Homoisoflavavone Sappanone A from Caesalpinia sappan
title_sort melanogenesis inhibition by homoisoflavavone sappanone a from caesalpinia sappan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431864/
https://www.ncbi.nlm.nih.gov/pubmed/22949866
http://dx.doi.org/10.3390/ijms130810359
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AT chaoshihyu melanogenesisinhibitionbyhomoisoflavavonesappanoneafromcaesalpiniasappan
AT dinghsiouyu melanogenesisinhibitionbyhomoisoflavavonesappanoneafromcaesalpiniasappan

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