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Distinct roles of AKT isoforms in regulating β1-integrin activity, migration, and invasion in prostate cancer

AKT1 and AKT2 kinases have been shown to play opposite roles in breast cancer migration and invasion. In this study, an RNA interference screen for integrin activity inhibitors identified AKT1 as an inhibitor of β1-integrin activity in prostate cancer. Validation experiments investigating all three...

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Detalles Bibliográficos
Autores principales:	Virtakoivu, Reetta, Pellinen, Teijo, Rantala, Juha K., Perälä, Merja, Ivaska, Johanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2012
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431929/ https://www.ncbi.nlm.nih.gov/pubmed/22809628 http://dx.doi.org/10.1091/mbc.E12-03-0213

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