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Structure and functional studies of N-terminal Cx43 mutants linked to oculodentodigital dysplasia

Mutations in the gene encoding connexin-43 (Cx43) cause the human development disorder known as oculodentodigital dysplasia (ODDD). In this study, ODDD-linked Cx43 N-terminal mutants formed nonfunctional gap junction–like plaques and exhibited dominant-negative effects on the coupling conductance of...

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Detalles Bibliográficos
Autores principales:	Shao, Qing, Liu, Qin, Lorentz, Robert, Gong, Xiang-Qun, Bai, Donglin, Shaw, Gary S., Laird, Dale W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2012
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431933/ https://www.ncbi.nlm.nih.gov/pubmed/22809623 http://dx.doi.org/10.1091/mbc.E12-02-0128

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