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Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function

To identify motifs involved in oligomerization of the gap junction protein Cx26, we studied individual transmembrane (TM) domains and the full-length protein. Using the TOXCAT assay for interactions of isolated TM α-helices, we found that TM1, a Cx26 pore domain, had a strong propensity to homodimer...

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Detalles Bibliográficos
Autores principales:	Jara, Oscar, Acuña, Rodrigo, García, Isaac E., Maripillán, Jaime, Figueroa, Vania, Sáez, Juan C., Araya-Secchi, Raúl, Lagos, Carlos F., Pérez-Acle, Tomas, Berthoud, Viviana M., Beyer, Eric C., Martínez, Agustín D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2012
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431943/ https://www.ncbi.nlm.nih.gov/pubmed/22787277 http://dx.doi.org/10.1091/mbc.E11-12-1058

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