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Collagen/β1 integrin signaling up-regulates the ABCC1/MRP-1 transporter in an ERK/MAPK-dependent manner

The mechanisms by which β1 integrins regulate chemoresistance of cancer cells are still poorly understood. In this study, we report that collagen/β1 integrin signaling inhibits doxorubicin-induced apoptosis of Jurkat and HSB2 leukemic T-cells by up-regulating the expression and function of the ATP-b...

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Detalles Bibliográficos
Autores principales:	El Azreq, Mohammed-Amine, Naci, Dalila, Aoudjit, Fawzi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2012
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431945/ https://www.ncbi.nlm.nih.gov/pubmed/22787275 http://dx.doi.org/10.1091/mbc.E12-02-0132

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