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Biochemical and Mass Spectrometric Characterization of Human N-Acylethanolamine-Hydrolyzing Acid Amidase Inhibition
The mechanism of inactivation of human enzyme N-acylethanolamine-hydrolyzing acid amidase (hNAAA), with selected inhibitors identified in a novel fluorescent based assay developed for characterization of both reversible and irreversible inhibitors, was investigated kinetically and using matrix-assis...
Autores principales: | West, Jay M., Zvonok, Nikolai, Whitten, Kyle M., Vadivel, Subramanian K., Bowman, Anna L., Makriyannis, Alexandros |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432061/ https://www.ncbi.nlm.nih.gov/pubmed/22952796 http://dx.doi.org/10.1371/journal.pone.0043877 |
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