Associations between LSAMP gene polymorphisms and major depressive disorder and panic disorder

The purpose of this case–control genetic association study was to explore potential relationships between polymorphisms in the limbic system-associated membrane protein (LSAMP) gene and mood and anxiety disorders. A total of 21 single-nucleotide polymorphisms (SNPs) from the LSAMP gene were analyzed...

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Autores principales: Koido, K, Traks, T, Balõtšev, R, Eller, T, Must, A, Koks, S, Maron, E, Tõru, I, Shlik, J, Vasar, V, Vasar, E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432189/
https://www.ncbi.nlm.nih.gov/pubmed/22892717
http://dx.doi.org/10.1038/tp.2012.74
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author Koido, K
Traks, T
Balõtšev, R
Eller, T
Must, A
Koks, S
Maron, E
Tõru, I
Shlik, J
Vasar, V
Vasar, E
author_facet Koido, K
Traks, T
Balõtšev, R
Eller, T
Must, A
Koks, S
Maron, E
Tõru, I
Shlik, J
Vasar, V
Vasar, E
author_sort Koido, K
collection PubMed
description The purpose of this case–control genetic association study was to explore potential relationships between polymorphisms in the limbic system-associated membrane protein (LSAMP) gene and mood and anxiety disorders. A total of 21 single-nucleotide polymorphisms (SNPs) from the LSAMP gene were analyzed in 591 unrelated patients with the diagnoses of major depressive disorder (MDD) or panic disorder (PD) and in 384 healthy control subjects. The results showed a strong association between LSAMP SNPs and MDD, and a suggestive association between LSAMP SNPs and PD. This is the first evidence of a possible role of LSAMP gene in mood and anxiety disorders in humans.
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spelling pubmed-34321892012-09-05 Associations between LSAMP gene polymorphisms and major depressive disorder and panic disorder Koido, K Traks, T Balõtšev, R Eller, T Must, A Koks, S Maron, E Tõru, I Shlik, J Vasar, V Vasar, E Transl Psychiatry Original Article The purpose of this case–control genetic association study was to explore potential relationships between polymorphisms in the limbic system-associated membrane protein (LSAMP) gene and mood and anxiety disorders. A total of 21 single-nucleotide polymorphisms (SNPs) from the LSAMP gene were analyzed in 591 unrelated patients with the diagnoses of major depressive disorder (MDD) or panic disorder (PD) and in 384 healthy control subjects. The results showed a strong association between LSAMP SNPs and MDD, and a suggestive association between LSAMP SNPs and PD. This is the first evidence of a possible role of LSAMP gene in mood and anxiety disorders in humans. Nature Publishing Group 2012-08 2012-08-14 /pmc/articles/PMC3432189/ /pubmed/22892717 http://dx.doi.org/10.1038/tp.2012.74 Text en Copyright © 2012 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Original Article
Koido, K
Traks, T
Balõtšev, R
Eller, T
Must, A
Koks, S
Maron, E
Tõru, I
Shlik, J
Vasar, V
Vasar, E
Associations between LSAMP gene polymorphisms and major depressive disorder and panic disorder
title Associations between LSAMP gene polymorphisms and major depressive disorder and panic disorder
title_full Associations between LSAMP gene polymorphisms and major depressive disorder and panic disorder
title_fullStr Associations between LSAMP gene polymorphisms and major depressive disorder and panic disorder
title_full_unstemmed Associations between LSAMP gene polymorphisms and major depressive disorder and panic disorder
title_short Associations between LSAMP gene polymorphisms and major depressive disorder and panic disorder
title_sort associations between lsamp gene polymorphisms and major depressive disorder and panic disorder
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432189/
https://www.ncbi.nlm.nih.gov/pubmed/22892717
http://dx.doi.org/10.1038/tp.2012.74
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