Cargando…

Epistasis network centrality analysis yields pathway replication across two GWAS cohorts for bipolar disorder

Most pathway and gene-set enrichment methods prioritize genes by their main effect and do not account for variation due to interactions in the pathway. A portion of the presumed missing heritability in genome-wide association studies (GWAS) may be accounted for through gene–gene interactions and add...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pandey, A, Davis, N A, White, B C, Pajewski, N M, Savitz, J, Drevets, W C, McKinney, B A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432194/ https://www.ncbi.nlm.nih.gov/pubmed/22892719 http://dx.doi.org/10.1038/tp.2012.80

Ejemplares similares

Six Degrees of Epistasis: Statistical Network Models for GWAS
por: McKinney, B. A., et al.
Publicado: (2012)

Nearest-Neighbor Projected Distance Regression for Epistasis Detection in GWAS With Population Structure Correction
por: Arabnejad, Marziyeh, et al.
Publicado: (2020)

The Integration of Epistasis Network and Functional Interactions in a GWAS Implicates RXR Pathway Genes in the Immune Response to Smallpox Vaccine
por: McKinney, Brett A., et al.
Publicado: (2016)

Performance of epistasis detection methods in semi-simulated GWAS
por: Chatelain, Clément, et al.
Publicado: (2018)

Surfing a genetic association interaction network to identify modulators of antibody response to smallpox vaccine
por: Davis, N A, et al.
Publicado: (2010)

Identification and replication of RNA-Seq gene network modules associated with depression severity
por: Le, Trang T., et al.
Publicado: (2018)

Correction: Identification and replication of RNA-Seq gene network modules associated with depression severity
por: Le, Trang T., et al.
Publicado: (2020)

Novel Alzheimer’s disease genes and epistasis identified using machine learning GWAS platform
por: Lundberg, Mischa, et al.
Publicado: (2023)

Transition-transversion encoding and genetic relationship metric in ReliefF feature selection improves pathway enrichment in GWAS
por: Arabnejad, M., et al.
Publicado: (2018)

Mitochondrial GWAS and association of nuclear – mitochondrial epistasis with BMI in T1DM patients
por: Ludwig-Słomczyńska, Agnieszka H., et al.
Publicado: (2020)

Minocycline and aspirin in the treatment of bipolar depression: a protocol for a proof-of-concept, randomised, double-blind, placebo-controlled, 2×2 clinical trial
por: Savitz, Jonathan, et al.
Publicado: (2012)

Leveraging putative enhancer-promoter interactions to investigate two-way epistasis in Type 2 Diabetes GWAS
por: Manduchi, Elisabetta, et al.
Publicado: (2018)

Detection and replication of epistasis influencing transcription in humans
por: Hemani, Gibran, et al.
Publicado: (2014)

Higher-order epistasis and phenotypic prediction
por: Zhou, Juannan, et al.
Publicado: (2022)

PheGWAS: a new dimension to visualize GWAS across multiple phenotypes
por: George, Gittu, et al.
Publicado: (2020)

Replicating animal mitochondrial DNA
por: McKinney, Emily A., et al.
Publicado: (2013)

Replication of genome‐wide association study (GWAS) susceptibility loci in a Latino bipolar disorder cohort
por: Gonzalez, Suzanne, et al.
Publicado: (2016)

Treatment of bipolar depression with minocycline and/or aspirin: an adaptive, 2×2 double-blind, randomized, placebo-controlled, phase IIA clinical trial
por: Savitz, Jonathan B., et al.
Publicado: (2018)

Clinical application of brain imaging for the diagnosis of mood disorders: the current state of play
por: Savitz, J B, et al.
Publicado: (2013)

Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability
por: Duncan, L E, et al.
Publicado: (2018)

Replication and Explorations of High-Order Epistasis Using a Large Advanced Intercross Line Pedigree
por: Pettersson, Mats, et al.
Publicado: (2011)

Converging Evidence for Epistasis between ANK3 and Potassium Channel Gene KCNQ2 in Bipolar Disorder
por: Judy, Jennifer Toolan, et al.
Publicado: (2013)

Epistasis and Entropy
por: Crona, Kristina
Publicado: (2016)

Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-Americans
por: Ramos, E., et al.
Publicado: (2010)

Disentangling group specific QTL allele effects from genetic background epistasis using admixed individuals in GWAS: An application to maize flowering
por: Rio, Simon, et al.
Publicado: (2020)

Accounting for epistasis improves genomic prediction of phenotypes with univariate and bivariate models across environments
por: Vojgani, Elaheh, et al.
Publicado: (2021)

Epistasis regulates genetic control of cardiac hypertrophy
por: Wang, Qianru, et al.
Publicado: (2023)

Whole-Genome Quantitative Trait Locus Mapping Reveals Major Role of Epistasis on Yield of Rice
por: Huang, Anhui, et al.
Publicado: (2014)

Genome-Wide Association of Bipolar Disorder Suggests an Enrichment of Replicable Associations in Regions near Genes
por: Smith, Erin N., et al.
Publicado: (2011)

Q&A: Epistasis
por: Roth, Frederick P, et al.
Publicado: (2009)

Estimating directional epistasis
por: Le Rouzic, Arnaud
Publicado: (2014)

Epigenetics, epistasis and epidemics
por: Baquero, Fernando
Publicado: (2013)

Evolutionary footprint of epistasis
por: Pedruzzi, Gabriele, et al.
Publicado: (2018)

FastEpistasis: a high performance computing solution for quantitative trait epistasis
por: Schüpbach, Thierry, et al.
Publicado: (2010)

Detecting epistasis with the marginal epistasis test in genetic mapping studies of quantitative traits
por: Crawford, Lorin, et al.
Publicado: (2017)

Prevalence of Epistasis in the Evolution of Influenza A Surface Proteins
por: Kryazhimskiy, Sergey, et al.
Publicado: (2011)

Differential expression of MDGA1 in major depressive disorder
por: Li, Yijie (Jamie), et al.
Publicado: (2022)

Compartmentalized self-replication under fast PCR cycling conditions yields Taq DNA polymerase mutants with increased DNA-binding affinity and blood resistance
por: Arezi, Bahram, et al.
Publicado: (2014)

Temperature-dependent mitochondrial-nuclear epistasis
por: Cazares-Navarro, Enrique, et al.
Publicado: (2019)

Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease
por: Combarros, Onofre, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_rndu6mkd0vtcbitalgsi3f4ihd